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J Gen Virol 77 (1996), 1825-1831; DOI 10.1099/0022-1317-77-8-1825
© 1996 Society for General Microbiology
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Mutations in the envelope gene of hepatitis B virus variants co-occurring with antibody to surface antigen in sera from patients with chronic hepatitis B

Hiroki Kohno1, Taisuke Inoue1, Fumio Tsuda2, Hiroaki Okamoto3 and Yoshihiro Akahane1

1 First Department of Internal Medicine, Yamanashi Medical University, Yamanashi-Ken 409-38, Japan
2 Department of Medical Sciences, Toshiba General Hospital, Tokyo 140, Japan
3 Immunology Division, Jichi Medical School, Tochigi-Ken 329-04, Japan

Three clones of hepatitis B virus (HBV) DNA were propagated from sera of each of five patients with chronic hepatitis B who possessed hepatitis B surface antigen (HBsAg) and antibody to HBsAg in their serum. The clones were sequenced within the envelope gene (the preS1, preS2 regions and the S gene). Clones from four patients had various missense mutations involving codons 124–147 of the S-gene which encode amino acids in the loop structures that form the conformational, common antigenic determinant of HBsAg. Clones from three patients had Asn-130 (Gly in the wild-type), which generated a potential N-glycosylation site, Asn-Thr-Ser, spanning amino acids 130–132 of the S-gene product. In addition, clones from one patient had Arg-145 (Gly in the wild-type), which has been reported in escape mutants of HBV. One of the three clones from another patient had Ser-126 in place of Ile or Thr in wild-type HBV, but the remaining two had no mutations known to affect expression of the common determinant of HBsAg. The remaining patient possessed HBsAg of subtype adr and anti-HBs specific for the w determinant. Clones from this patient did not reveal any mutations which are known to affect the common antigenic determinant of HBsAg.

Received 18 December 1995; accepted 19 March 1996.


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