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J Gen Virol 78 (1997), 2901-2907
© 1997 Society for General Microbiology
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Journal of General Virology, Vol 78, 2901-2907, Copyright © 1997 by Society for General Microbiology

ARTICLES

Resistance to herpes simplex virus type 1 and its latent infection of human T cell lymphotropic virus type I-transformed T cell lines of rabbits

A Seto, Y Nagano, T Isono and M Kurokawa
Department of Microbiology, Faculty of Medicine, Shiga University of Medical Science, Otsu, Japan. seto@belle.shiga-med.ac.jp

Fourteen T cell lines of rabbits were infected with herpes simplex virus type 1 (HSV-1) and examined for their susceptibility to lytic infection and ability to support virus replication. T cell lines of CD4+ 8- phenotype were more vulnerable to lysis and supported higher levels of virus replication than those of other phenotypes. Cell lines of CD4+ 8+ and CD4- 8+ phenotypes continued to proliferate, while remaining productively infected, for more than a month. These latently infected cell lines could be established by treatment with anti-HSV-1 serum and complement. Viral genes were only partially expressed and the CD8 membrane antigen was down-regulated. Infected cell lines, as well as peripheral blood lymphocytes, were shown to induce meningoencephalitis when inoculated intravenously into syngeneic hosts, suggesting a possible role for infected lymphocytes in HSV-1 transport in vivo.




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