Journal of General Virology, Vol 78, 2909-2912, Copyright © 1997 by Society for General Microbiology

ARTICLES

Induction of apoptosis by herpes simplex virus type 1

AH Koyama and A Adachi
Department of Virology, School of Medicine, The University of Tokushima, Japan. koyama@basic.med.tokushima-u.ac.jp

Although herpes simplex virus type 1 (HSV-1) does not induce apoptosis in infected HEp-2 cells, in the presence of cycloheximide infection induced apoptosis with characteristic morphological changes as well as endonucleosomal DNA cleavage. The induction of apoptosis without de novo protein synthesis suggests that a structural protein of the HSV-1 virion is responsible for the observed apoptosis.

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