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Journal of General Virology, Vol 78, 3327-3331, Copyright © 1997 by Society for General Microbiology
ARTICLES |
A Phelan and JB Clements
Institute of Virology, University of Glasgow, UK.
Herpes simplex virus type 1 (HSV-1) immediate early protein IE63, an essential nuclear protein, is pleiotropic in function and, at the post- transcriptional level, inhibits RNA splicing, interacts with cellular splicing small nuclear ribonucleoprotein particles (snRNPs), binds RNA and prevents the nucleocytoplasmic transport of intron-containing mRNAs. Here it is reported that IE63 is a nucleocytoplasmic shuttle protein able to travel from snRNP- and RNA-rich nuclear foci to the cytoplasm, where it accumulates during actinomycin D treatment. This newly identified property suggests that IE63 facilitates nuclear export of HSV-1 transcripts, in addition to retaining intron-containing transcripts in the nucleus. The mechanism by which IE63 controls RNA export has yet to be defined.
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G. Farjot, M. Buisson, M. Duc Dodon, L. Gazzolo, A. Sergeant, and I. Mikaelian Epstein-Barr Virus EB2 Protein Exports Unspliced RNA via a Crm-1-Independent Pathway J. Virol., July 1, 2000; 74(13): 6068 - 6076. [Abstract] [Full Text]
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P. Cheung, K. S. Ellison, R. Verity, and J. R. Smiley Herpes Simplex Virus ICP27 Induces Cytoplasmic Accumulation of Unspliced Polyadenylated alpha -Globin Pre-mRNA in Infected HeLa Cells J. Virol., March 15, 2000; 74(6): 2913 - 2919. [Abstract] [Full Text]
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 L. J. Bello, A. J. Davison, M. A. Glenn, A. Whitehouse, N. Rethmeier, T. F. Schulz, and J. Barklie Clements The human herpesvirus-8 ORF 57 gene and its properties J. Gen. Virol., December 1, 1999; 80(12): 3207 - 3215. [Abstract] [Full Text]
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D. J. Goodwin, K. T. Hall, A. J. Stevenson, A. F. Markham, and A. Whitehouse The Open Reading Frame 57 Gene Product of Herpesvirus Saimiri Shuttles between the Nucleus and Cytoplasm and Is Involved in Viral RNA Nuclear Export J. Virol., December 1, 1999; 73(12): 10519 - 10524. [Abstract] [Full Text]
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S. Wadd, H. Bryant, O. Filhol, J. E. Scott, T.-Y. Hsieh, R. D. Everett, and J. B. Clements The Multifunctional Herpes Simplex Virus IE63 Protein Interacts with Heterogeneous Ribonucleoprotein K and with Casein Kinase 2 J. Biol. Chem., October 8, 1999; 274(41): 28991 - 28998. [Abstract] [Full Text] [PDF]
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M. Buisson, F. Hans, I. Kusters, N. Duran, and A. Sergeant The C-Terminal Region but Not the Arg-X-Pro Repeat of Epstein-Barr Virus Protein EB2 Is Required for Its Effect on RNA Splicing and Transport J. Virol., May 1, 1999; 73(5): 4090 - 4100. [Abstract] [Full Text]
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Y. Zhi and R. M. Sandri-Goldin Analysis of the Phosphorylation Sites of Herpes Simplex Virus Type 1 Regulatory Protein ICP27 J. Virol., April 1, 1999; 73(4): 3246 - 3257. [Abstract] [Full Text]
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L. E. Hann, W. J. Cook, S. L. Uprichard, D. M. Knipe, and D. M. Coen The Role of Herpes Simplex Virus ICP27 in the Regulation of UL24 Gene Expression by Differential Polyadenylation J. Virol., October 1, 1998; 72(10): 7709 - 7714. [Abstract] [Full Text] [PDF]
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T. Wolff, R. E. O'Neill, and P. Palese NS1-Binding Protein (NS1-BP): a Novel Human Protein That Interacts with the Influenza A Virus Nonstructural NS1 Protein Is Relocalized in the Nuclei of Infected Cells J. Virol., September 1, 1998; 72(9): 7170 - 7180. [Abstract] [Full Text] [PDF]
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