Journal of General Virology, Vol 78, 367-372, Copyright © 1997 by Society for General Microbiology

ARTICLES

Genetic diversity of the attachment (H) protein gene of current field isolates of canine distemper virus

G Bolt, TD Jensen, E Gottschalck, P Arctander, MJ Appel, R Buckland and M Blixenkrone-Moller
Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.

To characterize the variability of recent field isolates of canine distemper virus (CDV) from different hosts and geographical areas, we conducted nucleotide sequence analysis of the gene encoding the haemagglutinin (H), the attachment protein of this virus. Pronounced differences between field isolates were revealed in comparison to the Convac and Onderstepoort vaccine strains. The diversity of CDV appeared to exceed that determined for measles virus. Phylogenetic analysis also separated the field isolates of CDV from the vaccine strains and provided evidence for the existence of different contemporary genotypes of CDV. Isolates from a Greenlandic sledge dog and a Siberian seal formed a distinct lineage. The remaining isolates formed a group. This group contained two European isolates from mink and ferret, a single lineage comprising three European dog isolates, and another separate lineage of North American isolates from dog, javelina, raccoon and captive leopards.

This article has been cited by other articles:

				S. Kapil, R. W. Allison, L. Johnston III, B. L. Murray, S. Holland, J. Meinkoth, and B. Johnson Canine Distemper Virus Strains Circulating among North American Dogs Clin. Vaccine Immunol., April 1, 2008; 15(4): 707 - 712. [Abstract] [Full Text] [PDF]

				I. D. R. Pardo, G. C. Johnson, and S. B. Kleiboeker Phylogenetic Characterization of Canine Distemper Viruses Detected in Naturally Infected Dogs in North America J. Clin. Microbiol., October 1, 2005; 43(10): 5009 - 5017. [Abstract] [Full Text] [PDF]

				M. Mochizuki, M. Motoyoshi, K. Maeda, and K. Kai Complement-Mediated Neutralization of Canine Distemper Virus In Vitro: Cross-Reaction between Vaccine Onderstepoort and Field KDK-1 Strains with Different Hemagglutinin Gene Characteristics Clin. Vaccine Immunol., July 1, 2002; 9(4): 921 - 924. [Abstract] [Full Text] [PDF]

				J. F. Evermann, C. W. Leathers, J. R. Gorham, A. J. McKeirnan, and M. J. G. Appel Pathogenesis of Two Strains of Lion (Panthera leo) Morbillivirus in Ferrets (Mustela putorius furo) Vet. Pathol., May 1, 2001; 38(3): 311 - 316. [Abstract] [Full Text] [PDF]

				M. Mochizuki, M. Hashimoto, S. Hagiwara, Y. Yoshida, and S. Ishiguro Genotypes of Canine Distemper Virus Determined by Analysis of the Hemagglutinin Genes of Recent Isolates from Dogs in Japan J. Clin. Microbiol., September 1, 1999; 37(9): 2936 - 2942. [Abstract] [Full Text]

				V. von Messling, T. C. Harder, V. Moennig, P. Rautenberg, I. Nolte, and L. Haas Rapid and Sensitive Detection of Immunoglobulin M (IgM) and IgG Antibodies against Canine Distemper Virus by a New Recombinant Nucleocapsid Protein-Based Enzyme-Linked Immunosorbent Assay J. Clin. Microbiol., April 1, 1999; 37(4): 1049 - 1056. [Abstract] [Full Text]

				P. Cherpillod, K. Beck, A. Zurbriggen, and R. Wittek Sequence Analysis and Expression of the Attachment and Fusion Proteins of Canine Distemper Virus Wild-Type Strain A75/17 J. Virol., March 1, 1999; 73(3): 2263 - 2269. [Abstract] [Full Text]