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J Gen Virol 78 (1997), 567-570
© 1997 Society for General Microbiology
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Journal of General Virology, Vol 78, 567-570, Copyright © 1997 by Society for General Microbiology

ARTICLES

Inactivation of inhibitors by the receptor-destroying enzyme of influenza C virus

K Hofling, HD Klenk and G Herrler
Institut fur Virologie, Philipps-Universitat Marburg, Germany.

The importance of the receptor-destroying enzyme of influenza C virus for inactivation of inhibitors was analysed. Using three different inhibitors (rat serum, bovine submandibulary mucin and bovine brain gangliosides) inhibition of virus infection was observed only at an inhibitor concentration that was about 100-fold higher than the maximum concentration of inhibitor that could be inactivated by the receptor- destroying enzyme of a given amount of virus. From our data and other observations we conclude that the receptor-destroying enzyme is not required to inactivate inhibitors.


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