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J Gen Virol 78 (1997), 821-824
© 1997 Society for General Microbiology
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Journal of General Virology, Vol 78, 821-824, Copyright © 1997 by Society for General Microbiology

ARTICLES

CD8+ cytotoxic T lymphocytes of a cynomolgus macaque infected with simian immunodeficiency virus (SIV) mac32H-J5 recognize a nine amino acid epitope in SIV Gag p26

AM Geretti, EG Hulskotte, ME Dings, CA van Baalen, G van Amerongen and AD Osterhaus
Institute of Virology, Erasmus University, Rotterdam, The Netherlands.

A detailed analysis of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocyte (CTL) responses and the identification of the proteins and epitopes they target may improve the design of immunotherapeutic interventions and provide insights into AIDS pathogenesis. Here, we identified a new CTL epitope in the SIV Gag protein, recognized by CD8+ and MHC class I-restricted CTL clones from a long-term asymptomatic cynomolgus macaque (Macaca fascicularis) infected with SIVmac32H-J5. Using overlapping synthetic peptides, the optimal minimal epitope was characterized as a nine amino acid peptide representing amino acids 242-250 of p26 (SVDEQIQWM). CTL recognition was shown to be abolished by amino acid substitutions observed within homologous human immunodeficiency virus (HIV)-1 and HIV-2 sequences.


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D. R. M. Negri, M. Borghi, S. Baroncelli, I. Macchia, V. Buffa, L. Sernicola, P. Leone, F. Titti, and A. Cara
Identification of a cytotoxic T-lymphocyte (CTL) epitope recognized by Gag-specific CTLs in cynomolgus monkeys infected with simian/human immunodeficiency virus.
J. Gen. Virol., November 1, 2006; 87(Pt 11): 3385 - 3392.
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