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J Gen Virol 78 (1997), 1119-1124
© 1997 Society for General Microbiology
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Journal of General Virology, Vol 78, 1119-1124, Copyright © 1997 by Society for General Microbiology

ARTICLES

Transmission of equine herpesvirus 2 to the mouse: characterization of a new laboratory infection model

SM Rizvi, JD Slater, AJ Slade and HJ Field
Centre for Veterinary Science, University of Cambridge, UK.

Intranasal inoculation of BALB/c mice with a recent clinical isolate of equine herpesvirus 2 (EHV-2 strain MR) produced a productive infection characterized by clinical signs, including weight-loss and conjunctivitis, but no mortality. Infectious virus was isolated from the lung, trachea and nasal turbinates with the highest titres present in lung tissue; EHV-2 neutralizing antibody was detected in the serum on day 21 post-inoculation. No infectious virus was detected in neural tissue, blood or lymphoid tissues. An EHV-2-specific nested PCR confirmed the presence of EHV-2 DNA in the respiratory tissues. In addition, EHV-2 DNA was detected in the trigeminal ganglia and olfactory bulbs from the first day after inoculation and these tissues remained positive for EHV-2 DNA for at least 30 days, by which time EHV- 2 DNA had been cleared from all other tissues.


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