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J Gen Virol 78 (1997), 1353-1356
© 1997 Society for General Microbiology
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Journal of General Virology, Vol 78, 1353-1356, Copyright © 1997 by Society for General Microbiology

ARTICLES

Yellow fever virus envelope protein has two discrete type-specific neutralizing epitopes

KD Ryman, TN Ledger, RC Weir, JJ Schlesinger and AD Barrett
Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555, USA.

Two monoclonal antibody neutralization resistant (MAbR) variants of the yellow fever (YF) 17D-204 vaccine virus strain were selected using YF type-specific MAb B39. These B39R variants were compared with the variant virus selected by Lobigs et al. (Virology 161, 474-478, 1987) using a second YF-type specific MAb (2E10) which mapped to amino acid position 71/72 in the envelope (E) protein. Neutralization assays with a panel of MAbs suggested that these two YF-type-specific epitopes are located in two discrete regions of the folded E protein. Each of the B39R variants had a single nucleotide mutation which encoded an amino acid substitution at either position E-155 or E-158. Thus, YF type- specific epitopes map to both domain I (B39) and II (2E10) of the YF virus E protein. The B39 defined epitope represents the first flavivirus neutralizing epitope localized to this region of domain I of the E protein.


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