J Gen Virol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 78 (1997), 1405-1409
© 1997 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vella, C.
Right arrow Articles by Daniels, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vella, C.
Right arrow Articles by Daniels, R.
Agricola
Right arrow Articles by Vella, C.
Right arrow Articles by Daniels, R.

Journal of General Virology, Vol 78, 1405-1409, Copyright © 1997 by Society for General Microbiology

ARTICLES

Herpesvirus saimiri-immortalized human T-cells support long-term, high titred replication of human immunodeficiency virus types 1 and 2

C Vella, H Fickenscher, C Atkins, M Penny and R Daniels
National Institute for Medical Research, London, UK.

Herpesvirus saimiri strain C488 transforms human CD4+ T-lymphocytes to continuous interleukin-2-dependent growth. Unlike human T-cell lines derived from tumours or those transformed by human T-lymphotropic virus 1, herpesvirus saimiri-immortalized T-cells (HVS T-cells) retain many functions of primary activated T-lymphocytes. We have characterized the course of human immunodeficiency virus types 1 and 2 (HIV-1/-2) infection in three HVS T-cell lines. Our results confirm that HVS T- cells are highly permissive to both HIV-1/-2 prototype viruses and to poorly replicating HIV-2 strains of restricted cell tropism. However, the infection was persistently productive for up to 5 months. The down- regulation of surface CD4 molecules was delayed and virus yields significantly exceeded those obtained in T-cell lines.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
E. M. Sorokina, J. J. Merlo Jr., and A. Y. Tsygankov
Molecular Mechanisms of the Effect of Herpesvirus saimiri Protein StpC on the Signaling Pathway Leading to NF-{kappa}B Activation
J. Biol. Chem., April 2, 2004; 279(14): 13469 - 13477.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
N. N. Zheng, C. Vella, P. J. Easterbrook, and R. S. Daniels
Selection following isolation of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and herpesvirus saimiri-transformed T cells is comparable
J. Gen. Virol., June 1, 2002; 83(6): 1343 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Bauer, M. Lucchiari-Hartz, H. Fickenscher, K. Eichmann, J. McKeating, and A. Meyerhans
Herpesvirus Saimiri-Transformed Human CD4+ T-Cell Lines: an Efficient Target Cell System for the Analysis of Human Immunodeficiency Virus-Specific Cytotoxic CD8+ T-Lymphocyte Activity
J. Virol., February 1, 1998; 72(2): 1627 - 1631.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1997 by the Society for General Microbiology.