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J Gen Virol 78 (1997), 1605-1610
© 1997 Society for General Microbiology
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Journal of General Virology, Vol 78, 1605-1610, Copyright © 1997 by Society for General Microbiology

ARTICLES

Molecular characterization of attenuated Junin virus strains

CG Albarino, PD Ghiringhelli, DM Posik, ME Lozano, AM Ambrosio, A Sanchez and V Romanowski
Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.

The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.


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