J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 78 (1997), 2315-2318
© 1997 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boga, J. A.
Right arrow Articles by Parra, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boga, J. A.
Right arrow Articles by Parra, F.
Agricola
Right arrow Articles by Boga, J. A.
Right arrow Articles by Parra, F.

Journal of General Virology, Vol 78, 2315-2318, Copyright © 1997 by Society for General Microbiology

ARTICLES

A single dose immunization with rabbit haemorrhagic disease virus major capsid protein produced in Saccharomyces cerevisiae induces protection

JA Boga, JM Martin Alonso, R Casais and F Parra
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Oviedo, Spain.

The gene coding for the major capsid protein (VP60) from rabbit haemorrhagic disease virus was expressed in Saccharomyces cerevisiae under the phosphoglycerate kinase promoter. The recombinant VP60 produced in yeast was antigenically similar to the viral polypeptide as determined with a polyclonal serum. Electron microscopic observation of the recombinant yeast-derived antigen revealed the presence of virus- like particles similar in size and appearance to native capsids. Subcutaneous vaccination of rabbits with a single dose of this antigen in the absence of commercial adjuvants conferred complete protection against the haemorrhagic disease.


This article has been cited by other articles:


Home page
 J. Virol.Home page
J. Bárcena, M. Morales, B. Vázquez, J. A. Boga, F. Parra, J. Lucientes, A. Pagès-Manté, J. M. Sánchez-Vizcaíno, R. Blasco, and J. M. Torres
Horizontal Transmissible Protection against Myxomatosis and Rabbit Hemorrhagic Disease by Using a Recombinant Myxoma Virus
J. Virol., February 1, 2000; 74(3): 1114 - 1123.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
S. Castañón, M. S. Marín, J. M. Martín-Alonso, J. A. Boga, R. Casais, J. M. Humara, R. J. Ordás, and F. Parra
Immunization with Potato Plants Expressing VP60 Protein Protects against Rabbit Hemorrhagic Disease Virus
J. Virol., May 1, 1999; 73(5): 4452 - 4455.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1997 by the Society for General Microbiology.