Journal of General Virology, Vol 79, 27-30, Copyright © 1998 by Society for General Microbiology

ARTICLES

Evidence for biotype-specific effects of bovine viral diarrhoea virus on biological responses in acutely infected calves

M Lambot, E Joris, A Douart, J Lyaku, JJ Letesson and PP Pastoret
Department of Immunology/Vaccinology, Faculty of Veterinary Medicine, University of Liege, Belgium. Lambot@stat.fmv.ulg.ac.be

The relationship between the two biotypes of bovine viral diarrhoea virus (BVDV) and the biological responses they induce was studied in 3- to 6-month-old calves inoculated intranasally with a homologous pair of non-cytopathic and cytopathic strains. Marked differences in virological and serological events occurred following exposure to a specific BVDV strain. The non-cytopathic biotype was frequently recovered from nasal secretions and blood cells during the first 28 days post-inoculation whereas the cytopathic counterpart was detected infrequently in nasopharyngeal swabs only. There was no correlation of the recovery of infectious virus in vivo with the biotype-specific neutralizing humoral immune response. Furthermore, seroconversion did not correlate with resistance to reinfection as judged by the transient viraemia and/or shedding of virus observed in a challenge experiment.

This article has been cited by other articles:

				L. S. Brackenbury, B. V. Carr, Z. Stamataki, H. Prentice, E. A. Lefevre, C. J. Howard, and B. Charleston Identification of a Cell Population That Produces Alpha/Beta Interferon In Vitro and In Vivo in Response to Noncytopathic Bovine Viral Diarrhea Virus J. Virol., June 15, 2005; 79(12): 7738 - 7744. [Abstract] [Full Text] [PDF]

				S. Swasdipan, H. Bielefeldt-Ohmann, N. Phillips, P. D. Kirkland, and M. R. McGowan Rapid Transplacental Infection with Bovine Pestivirus Following Intranasal Inoculation of Ewes in Early Pregnancy Vet. Pathol., May 1, 2001; 38(3): 275 - 280. [Abstract] [Full Text] [PDF]