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Journal of General Virology, Vol 79, 41-45, Copyright © 1998 by Society for General Microbiology

ARTICLES

Genomic analysis of two GB virus A variants isolated from captive monkeys

JC Erker, SM Desai, TP Leary, ML Chalmers, CC Montes and IK Mushahwar
Virus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IL 60064, USA. James.Erker@add.ssw.abbott.com

The recent isolation of GB viruses A and B from GB agent infected tamarins and their lack of involvement in human hepatitis has sparked interest in the origin of these viruses. Several healthy non-human primate species have been shown to harbour sequences 52-79% identical to the GBV-A 5' nontranslated region. In this paper we report the near genome length sequence of GBV-Amx 70047 and GBV-Atri 1122. These sequences support previous observations about the genomic organization of GBV-A and provide insight into the genomic variability within this virus genus. Although the GBV-A variant polyproteins possess many motifs conserved between other members of the Flaviviridae, they do not encode a basic core-like protein. Amino acid sequence comparisons and phylogenetic analysis demonstrate variability within the GBV-A genus similar to that observed between hepatitis C virus (HCV) types. However, genomic organization and disease association demonstrate a closer evolutionary relationship to GBV-C than to HCV.


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