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Journal of General Virology, Vol 79, 51-55, Copyright © 1998 by Society for General Microbiology


ARTICLES

Characterization of a simian T-lymphotropic virus from a wild-caught orang-utan (Pongo pygmaeus) from Kalimantan, Indonesia

EJ Verschoor, KS Warren, H Niphuis, , RA Swan and JL Heeney
Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. verschoor@bprc.nl

In a recent serological survey among 143 ex-captive orang-utans two individuals were found that reacted positive in an ELISA detecting antibodies which cross-react with human T-lymphotropic virus type I (HTLV-I) antigens. Infection of both animals with an HTLV-I or simian T- lymphotropic virus (STLV)-like virus was confirmed by Western blot analysis. A third wild-caught animal, which was not part of the original serological survey, was also found to be infected with an HTLV- related virus in a diagnostic PCR assay and Western blot assay. Nucleotide sequence analysis of the 709 bp PCR fragment from the tax/rex region of the HTLV/STLV genome confirmed infection of orang- utans with an STLV similar to but clearly distinct from other Asian STLVs.


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