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Journal of General Virology, Vol 79, 2529-2532, Copyright © 1998 by Society for General Microbiology

ARTICLES

Identification of a novel multifunctional structural domain in the herpes simplex virus type 1 genome: implications for virus latency

JP Quinn, RA McGregor, CE Fiskerstrand, C Davey, J Allan and RG Dalziel
Department of Veterinary Pathology, University of Edinburgh, UK.

A domain, previously termed RE1, exists within the herpes simplex virus type 1 genome potentially influencing expression of immediate early genes and the latency associated transcripts. This domain consists of 10 tandem copies of a CT-rich sequence. We demonstrate that this domain binds multiple host-cell factors that may allow RE1 to act either as a transcriptional regulator and/or to affect nucleosomal and DNA structure in the latent genome.


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