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Journal of General Virology, Vol 79, 3085-3089, Copyright © 1998 by Society for General Microbiology
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S Viazov, RS Ross, C Niel, JM de Oliveira, C Varenholz, G Da Villa and M Roggendorf
Institute of Virology, University of Essen, Robert-Koch-Haus, Germany. sergei.viazov@uni-essen.de
Recently a new human virus, TT virus (TTV) was identified in the serum of a patient with post-transfusion hepatitis of unknown aetiology. Comparative sequence analysis of a 222 nt fragment of ORF 1 of TTV was performed to assess the genomic variability of this virus. Phylogenetic analysis of the nucleotide sequences of 76 TTV isolates collected in 17 countries segregated them into two major groups: TTV 1 and TTV 2. The TTV 1 group comprised two distinct subgroups, which corresponded to previously described TTV subtypes 1a and 1b. The TTV 2 group was separated into four main branches, two of which included sequences previously provisionally attributed as TTV types 2 and 3. Bootstrap resampling, however, did not support the reliability of this grouping, suggesting that the isolates in the TTV 2 group should be considered as subtypes of a single type rather than different TTV types.
This article has been cited by other articles:
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  M. Bendinelli, M. Pistello, F. Maggi, C. Fornai, G. Freer, and M. L. Vatteroni Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans Clin. Microbiol. Rev., January 1, 2001; 14(1): 98 - 113. [Abstract] [Full Text] [PDF]
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 R. Romeo, P. Hegerich, S. U. Emerson, M. Colombo, R. H. Purcell, and J. Bukh High prevalence of TT virus (TTV) in naive chimpanzees and in hepatitis C virus-infected humans: frequent mixed infections and identification of new TTV genotypes in chimpanzees J. Gen. Virol., April 1, 2000; 81(4): 1001 - 1007. [Abstract] [Full Text]
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E. J. Verschoor, S. Langenhuijzen, and J. L. Heeney TT viruses (TTV) of non-human primates and their relationship to the human TTV genotypes J. Gen. Virol., September 1, 1999; 80(9): 2491 - 2499. [Abstract] [Full Text]
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 P. A. L. BONIS TT Virus J. Am. Soc. Nephrol., August 1, 1999; 10(8): 1828 - 1832. [Abstract] [Full Text]
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