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Journal of General Virology, Vol 79, 3173-3176, Copyright © 1998 by Society for General Microbiology

ARTICLES

The shortest known prion protein gene allele occurs in goats, has only three octapeptide repeats and is non-pathogenic

W Goldmann, A Chong, J Foster, J Hope and N Hunter
Institute for Animal Health, Neuropathogenesis Unit, Edinburgh, UK. wilfred.goldmann@bbsrc.ac.uk

The prion protein (PrP) gene modulates the incidence and incubation periods of transmissible spongiform encephalopathies of sheep, goats, mice and man. Here, a new caprine PrP allele encoding the shortest naturally occurring PrP protein so far described is reported. This variant contains only three instead of the usual five copies of a short peptide repeat [Pro-Gln/His-Gly-Gly-Gly-(Gly)-TrpGly-Gln] characteristic of PrP, with an additional Trp to Gly substitution in codon 102. Fifteen out of 111 genotyped goats carried the novel PrP allele and 14 survived without signs of disease for at least 4 years. One goat heterozygous for the polymorphism was challenged experimentally with SSBP/1-scrapie and succumbed after an unusually long incubation period.


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