J Gen Virol Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Damaso, C. R.
Right arrow Articles by Moussatche, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Damaso, C. R.
Right arrow Articles by Moussatche, N.
Agricola
Right arrow Articles by Damaso, C. R.
Right arrow Articles by Moussatche, N.

Journal of General Virology, Vol 79, 339-346, Copyright © 1998 by Society for General Microbiology

ARTICLES

Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins

CR Damaso and N Moussatche
Laboratorio de Biologia Molecular de Virus, Instituto de Biofisica Carlos Chagas Filho, CCS, UFRJ, Rio de Janeiro, Brazil.

The mechanism by which cyclosporin A (CsA) inhibits vaccinia virus (VV) replication is still unclear. The present study addresses the question of whether CsA-binding proteins named cyclophilins (Cyps) are involved in the anti-VV activity of CsA. Six CsA analogues were analysed, and their affinity for Cyps in VV-infected BSC-40 cells and their potency as inhibitors of VV replication were evaluated. It was demonstrated that analogues with strong Cyp-binding activity, such as CsC, CsG and [MeAla6]CsA, also exhibit a strong antiviral effect. In contrast, drugs with low ([MeBm2t1]CsA and CsH) or no ([MeLeu11]CsA) affinity for Cyps show poor or no antiviral activity. The data obtained suggest a correlation between the ability of CsA to block VV replication and Cyp binding activity, and indicate the involvement of Cyps in the VV replicative cycle. They also suggest that the anti-VV action of CsA may occur by a pathway distinct from that involved in the immunosuppressive effect of the drug.


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
R. G. Ptak, P. A. Gallay, D. Jochmans, A. P. Halestrap, U. T. Ruegg, L. A. Pallansch, M. D. Bobardt, M.-P. de Bethune, J. Neyts, E. De Clercq, et al.
Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent
Antimicrob. Agents Chemother., April 1, 2008; 52(4): 1302 - 1317.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Z. Keckesova, L. M. J. Ylinen, and G. J. Towers
Cyclophilin A Renders Human Immunodeficiency Virus Type 1 Sensitive to Old World Monkey but Not Human TRIM5{alpha} Antiviral Activity.
J. Virol., May 1, 2006; 80(10): 4683 - 4690.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. P. V. Castro, T. M. U. Carvalho, N. Moussatche, and C. R. A. Damaso
Redistribution of Cyclophilin A to Viral Factories during Vaccinia Virus Infection and Its Incorporation into Mature Particles
J. Virol., August 15, 2003; 77(16): 9052 - 9068.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1998 by the Society for General Microbiology.