Journal of General Virology, Vol 79, 609-612, Copyright © 1998 by Society for General Microbiology

ARTICLES

Effect of repeated oral infection of hamsters with scrapie

H Diringer, J Roehmel and M Beekes
Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany.

The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.

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