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Journal of General Virology, Vol 79, 1101-1104, Copyright © 1998 by Society for General Microbiology

ARTICLES

Spacing between the enhancer and promoter of the long terminal repeat of a murine leukaemia retrovirus is required for transcriptional activation in T cells

H Chen and FK Yoshimura
MediGene GmbH, Martinsried, Germany.

In T cells, transcriptional activation by the long terminal repeat (LTR) of the mink cell focus-forming murine leukaemia virus requires some spacing between the enhancer and promoter. A large size-range of intervening sequences (11-93 bp) is able to activate transcription efficiently. Neither a specific nucleotide sequence nor stereospecific alignment of the spacer is important.


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[Abstract] [Full Text] [PDF]


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