J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stannard, L. M.
Right arrow Articles by Dumbell, K. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stannard, L. M.
Right arrow Articles by Dumbell, K. R.
Agricola
Right arrow Articles by Stannard, L. M.
Right arrow Articles by Dumbell, K. R.

Journal of General Virology, Vol 79, 1637-1646, Copyright © 1998 by Society for General Microbiology

ARTICLES

Evidence for incomplete replication of a penguin poxvirus in cells of mammalian origin

LM Stannard, D Marais, D Kow and KR Dumbell
Department of Medical Microbiology, University of Cape Town Medical School, South Africa. stannard@medmicro.uct.ac.za

The recent discovery of a novel poxvirus [penguin-pox virus (PPV)] from Jackass penguins offers the potential of a unique candidate vaccine vector for use in mammals. Infectivity studies were therefore undertaken using a number of mammalian cell lines and chick embryo fibroblasts (CEF). It was shown that the simian CV-1 cell line was able to support replication of the PPV DNA, but no infectious progeny virus could be recovered from the infected cells. Electron microscopy was used to establish the extent of virus morphogenesis in CV-1 cells as compared to that in both chorio-allantoic membranes (CAMs) of hens' eggs and CEF cells. It appears that CV-1 cells are able to support partial maturation of PPV, but that morphogenesis does not proceed to the stage of mature infectious particles. Vaccinia virus promoters were successful in achieving transient gene expression in PPV-infected cells.


This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
K. Aspden, J.-A. Passmore, F. Tiedt, and A.-L. Williamson
Evaluation of lumpy skin disease virus, a capripoxvirus, as a replication-deficient vaccine vector
J. Gen. Virol., August 1, 2003; 84(8): 1985 - 1996.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
D. Marais,, J.-A. Passmore,, J. Maclean,, R. Rose, and A.-L. Williamson
A recombinant human papillomavirus (HPV) type 16 L1-vaccinia virus murine challenge model demonstrates cell-mediated immunity against HPV virus-like particles
J. Gen. Virol., September 1, 1999; 80(9): 2471 - 2475.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
M. Hollinshead, A. Vanderplasschen, G. L. Smith, and D. J. Vaux
Vaccinia Virus Intracellular Mature Virions Contain only One Lipid Membrane
J. Virol., February 1, 1999; 73(2): 1503 - 1517.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1998 by the Society for General Microbiology.