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Journal of General Virology, Vol 79, 1769-1773, Copyright © 1998 by Society for General Microbiology

ARTICLES

The cellular stress response increases measles virus-induced cytopathic effect

D Vasconcelos, E Norrby and M Oglesbee
Department of Veterinary Biosciences, The Ohio State University, Columbus 43210-1093, USA.

Plaque area is a measure of the degree of cytopathic effect and a predictor of neurovirulence for tissue culture adapted morbilliviruses. In the present work, the cellular stress response was shown to be a determinant of the expression of distinct measles virus large plaque phenotypes in Vero cells. The emergence of these large plaque phenotypes was associated with increased mean viral transcriptional activity and expression of the viral fusion glycoprotein, but not upregulation of the virus receptor CD46.


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