Journal of General Virology, Vol 79, 1997-2001, Copyright © 1998 by Society for General Microbiology

ARTICLES

Identification and transcriptional analysis of the homologues of the herpes simplex virus type 1 UL41 to UL51 genes in the genome of nononcogenic Marek's disease virus serotype 2

Y Izumiya, HK Jang, H Kashiwase, JS Cai, Y Nishimura, Y Tsushima, K Kato, T Miyazawa, C Kai and T Mikami
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Japan.

Studies on Marek's disease virus serotype 2 (MDV2) are important for understanding the natural nonpathogenic phenotypes of MDV. We determined the 16770 bp nucleotide sequence of the MDV2 genome located in the right part the of unique long region. The analysis revealed 12 complete open reading frames (ORFs) with high amino acid sequence identities to the gene products of other alphaherpesviruses. The MDV2 ORFs were arranged collinearly with the prototype sequence of herpes simplex virus type 1 ranging from the UL41 to UL51 genes. Except for the MDV2 UL41 gene, all of the identified genes were confirmed to be transcribed with 3'-coterminal mRNAs and/or a unique transcript in the virus-infected cells. Transcriptional patterns for the regions of the MDV2 UL48 to UL49.5 genes were notably different from the similar area of MDV serotype 1.

This article has been cited by other articles:

				F. Dorange, B. K. Tischer, J.-F. Vautherot, and N. Osterrieder Characterization of Marek's Disease Virus Serotype 1 (MDV-1) Deletion Mutants That Lack UL46 to UL49 Genes: MDV-1 UL49, Encoding VP22, Is Indispensable for Virus Growth J. Virol., February 15, 2002; 76(4): 1959 - 1970. [Abstract] [Full Text] [PDF]

				B. F. Kingham, V. Zelnik, J. Kopácek, V. Majerciak, E. Ney, and C. J. Schmidt The genome of herpesvirus of turkeys: comparative analysis with Marek's disease viruses J. Gen. Virol., May 1, 2001; 82(5): 1123 - 1135. [Abstract] [Full Text]

				F. Dorange, S. El Mehdaoui, C. Pichon, P. Coursaget, and J.-F. Vautherot Marek's disease virus (MDV) homologues of herpes simplex virus type 1 UL49 (VP22) and UL48 (VP16) genes: high-level expression and characterization of MDV-1 VP22 and VP16 J. Gen. Virol., September 1, 2000; 81(9): 2219 - 2230. [Abstract] [Full Text]

				W. Fuchs, K. Ziemann, J. P. Teifke, O. Werner, and T. C. Mettenleiter The non-essential UL50 gene of avian infectious laryngotracheitis virus encodes a functional dUTPase which is not a virulence factor J. Gen. Virol., March 1, 2000; 81(3): 627 - 638. [Abstract] [Full Text]

				Y. Izumiya, H.-K. Jang, M. Sugawara, Y. Ikeda, R. Miura, Y. Nishimura, K. Nakamura, T. Miyazawa, C. Kai, and T. Mikami Identification and transcriptional analysis of the homologues of the herpes simplex virus type 1 UL30 to UL40 genes in the genome of nononcogenic Marek's disease virus serotype 2 J. Gen. Virol., September 1, 1999; 80(9): 2417 - 2422. [Abstract] [Full Text]