|
|
||||||||
Journal of General Virology, Vol 79, 2079-2082, Copyright © 1998 by Society for General Microbiology
ARTICLES |
N Hunter and D Cairns
Institute for Animal Health, Neuropathogenesis Unit, Edinburgh, UK. NORA.HUNTER@BBSRC.AC.UK
As natural scrapie occurs only in sheep of specific PrP genotypes, one proposed aetiology was that scrapie is simply a genetic disease. However, Cheviot and Suffolk sheep of scrapie-susceptible genotypes are found in Australia and New Zealand, both generally accepted to be scrapie-free countries. A study of more common Australia and New Zealand sheep breeds (Merinos and Poll Dorsets) was carried out in order to obtain more generally applicable estimates of Australia and New Zealand sheep PrP genotype frequencies. We have confirmed that animals of highly susceptible PrP genotypes are found in Australia and New Zealand. Interestingly, the Poll Dorset sheep, although born in New Zealand, were brought to the UK as young adult animals and subsequently remained free of clinical scrapie despite 21% of the sheep having scrapie-susceptible genotypes. These results have implications for the genetic control of occurrence of the equivalent human diseases.
This article has been cited by other articles:
![]() |
L. Manuelidis, T. Chakrabarty, K. Miyazawa, N.-A. Nduom, and K. Emmerling The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt-Jakob disease and scrapie agents PNAS, August 11, 2009; 106(32): 13529 - 13534. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Gubbins Prevalence of sheep infected with classical scrapie in Great Britain: integrating multiple sources of surveillance data for 2002 J R Soc Interface, November 6, 2008; 5(28): 1343 - 1351. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. G. H. Hickford, H. Zhou, Q. Fang, S. O. Byun, and H. Gong Frequency of PRNP genotypes in common New Zealand sheep breeds Vet Rec., October 11, 2008; 163(15): 453 - 454. [Full Text] [PDF] |
||||
![]() |
C. Acin, I. Martin-Burriel, W. Goldmann, J. Lyahyai, M. Monzon, R. Bolea, A. Smith, C. Rodellar, J. J. Badiola, and P. Zaragoza Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep J. Gen. Virol., July 1, 2004; 85(7): 2103 - 2110. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Hunter Scrapie and experimental BSE in sheep Br. Med. Bull., June 1, 2003; 66(1): 171 - 183. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. F. Houston, S. I. Halliday, M. Jeffrey, W. Goldmann, and N. Hunter New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1) J. Gen. Virol., May 1, 2002; 83(5): 1247 - 1250. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bossers, R. de Vries, and M. A. Smits Susceptibility of Sheep for Scrapie as Assessed by In Vitro Conversion of Nine Naturally Occurring Variants of PrP J. Virol., February 1, 2000; 74(3): 1407 - 1414. [Abstract] [Full Text] |
||||
![]() |
S. Thorgeirsdottir, S. Sigurdarson, H. M. Thorisson, G. Georgsson, and A. Palsdottir PrP gene polymorphism and natural scrapie in Icelandic sheep J. Gen. Virol., September 1, 1999; 80(9): 2527 - 2534. [Abstract] [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |