J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peret, T. C.
Right arrow Articles by Anderson, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peret, T. C.
Right arrow Articles by Anderson, L. J.
Agricola
Right arrow Articles by Peret, T. C.
Right arrow Articles by Anderson, L. J.

Journal of General Virology, Vol 79, 2221-2229, Copyright © 1998 by Society for General Microbiology

ARTICLES

Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community

TC Peret, CB Hall, KC Schnabel, JA Golub and LJ Anderson
Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

Human respiratory syncytial virus (HRSV) is classified into two major groups, A and B, each of which contains multiple variants. To characterize the molecular epidemiology of HRSV strains over time, sequencing studies of a variable region of the attachment protein gene from a single community in the United States during 5 successive years were performed. Phylogenetic analysis revealed distinct clades (genotypes) that were further classified in subtypes based on > or = 96% nucleotide similarity. Five genotypes and 22 subtypes among 123 group A HRSV isolates, and four distinct genotypes and six subtypes among 81 group B HRSV isolates were identified. One to two genotypes or subtypes accounted for > or = 50% of isolates from a given year. A shift in the predominant genotype or subtype occurred each year such that no genotype or subtype predominated for more than 1 of the 5 study years. The consistency in the displacement of the predominant strain suggests that a shift, even within the same group, is advantageous to the virus. It was hypothesized that the 'novel' strain is better able to evade previously induced immunity in the population and consequently either circulates more efficiently or is more pathogenic. The yearly shift in HRSV strains may contribute to the ability of HRSV to consistently cause yearly outbreaks of HRSV disease. These results also suggest that isolates may need to be characterized as to both group and genotype to fully understand protective immunity after natural infection and efficacy studies of candidate vaccines.


This article has been cited by other articles:


Home page
 Int ImmunolHome page
M. Shingai, M. Azuma, T. Ebihara, M. Sasai, K. Funami, M. Ayata, H. Ogura, H. Tsutsumi, M. Matsumoto, and T. Seya
Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction
Int. Immunol., September 1, 2008; 20(9): 1169 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
K. T. Zlateva, L. Vijgen, N. Dekeersmaeker, C. Naranjo, and M. Van Ranst
Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic Seasons
J. Clin. Microbiol., September 1, 2007; 45(9): 3022 - 3030.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
S. Parveen, W. M. Sullender, K. Fowler, E. J. Lefkowitz, S. K. Kapoor, and S. Broor
Genetic variability in the g protein gene of group a and B respiratory syncytial viruses from India.
J. Clin. Microbiol., September 1, 2006; 44(9): 3055 - 3064.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
J. S. Kahn
Epidemiology of Human Metapneumovirus
Clin. Microbiol. Rev., July 1, 2006; 19(3): 546 - 557.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. Trento, M. Viegas, M. Galiano, C. Videla, G. Carballal, A. S. Mistchenko, and J. A. Melero
Natural History of Human Respiratory Syncytial Virus Inferred from Phylogenetic Analysis of the Attachment (G) Glycoprotein with a 60-Nucleotide Duplication
J. Virol., January 15, 2006; 80(2): 975 - 984.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. T. Zlateva, P. Lemey, E. Moes, A.-M. Vandamme, and M. Van Ranst
Genetic Variability and Molecular Evolution of the Human Respiratory Syncytial Virus Subgroup B Attachment G Protein
J. Virol., July 15, 2005; 79(14): 9157 - 9167.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
M. C. Galiano, C. Palomo, C. M. Videla, J. Arbiza, J. A. Melero, and G. Carballal
Genetic and Antigenic Variability of Human Respiratory Syncytial Virus (Groups A and B) Isolated over Seven Consecutive Seasons in Argentina (1995 to 2001)
J. Clin. Microbiol., May 1, 2005; 43(5): 2266 - 2273.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
M. Sato, R. Saito, T. Sakai, Y. Sano, M. Nishikawa, A. Sasaki, Y. Shobugawa, F. Gejyo, and H. Suzuki
Molecular Epidemiology of Respiratory Syncytial Virus Infections among Children with Acute Respiratory Symptoms in a Community over Three Seasons
J. Clin. Microbiol., January 1, 2005; 43(1): 36 - 40.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
N. Bastien, L. Liu, D. Ward, T. Taylor, and Y. Li
Genetic Variability of the G Glycoprotein Gene of Human Metapneumovirus
J. Clin. Microbiol., August 1, 2004; 42(8): 3532 - 3537.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
Y. Kuroiwa, K. Nagai, L. Okita, and H. Tsutsumi
Genetic Variability and Molecular Epidemiology of Respiratory Syncytial Virus Subgroup A Strains in Japan Determined by Heteroduplex Mobility Assay
J. Clin. Microbiol., May 1, 2004; 42(5): 2048 - 2053.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. T. Zlateva, P. Lemey, A.-M. Vandamme, and M. Van Ranst
Molecular Evolution and Circulation Patterns of Human Respiratory Syncytial Virus Subgroup A: Positively Selected Sites in the Attachment G Glycoprotein
J. Virol., May 1, 2004; 78(9): 4675 - 4683.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
T. C. T. Peret, Y. Abed, L. J. Anderson, D. D. Erdman, and G. Boivin
Sequence polymorphism of the predicted human metapneumovirus G glycoprotein
J. Gen. Virol., March 1, 2004; 85(3): 679 - 686.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
G. Boivin, S. Cote, P. Dery, G. De Serres, and M. G. Bergeron
Multiplex Real-Time PCR Assay for Detection of Influenza and Human Respiratory Syncytial Viruses
J. Clin. Microbiol., January 1, 2004; 42(1): 45 - 51.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
N. Bastien, D. Ward, P. Van Caeseele, K. Brandt, S. H. S. Lee, G. McNabb, B. Klisko, E. Chan, and Y. Li
Human Metapneumovirus Infection in the Canadian Population
J. Clin. Microbiol., October 1, 2003; 41(10): 4642 - 4646.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
L. P. Jones, H.-Q. Zheng, R. A. Karron, T. C. T. Peret, C. Tsou, and L. J. Anderson
Multiplex Assay for Detection of Strain-Specific Antibodies against the Two Variable Regions of the G Protein of Respiratory Syncytial Virus
Clin. Vaccine Immunol., May 1, 2002; 9(3): 633 - 638.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
H.-J. Shin, K. T. Cameron, J. A. Jacobs, E. A. Turpin, D. A. Halvorson, S. M. Goyal, K. V. Nagaraja, M. C. Kumar, D. C. Lauer, B. S. Seal, et al.
Molecular Epidemiology of Subgroup C Avian Pneumoviruses Isolated in the United States and Comparison with Subgroup A and B Viruses
J. Clin. Microbiol., May 1, 2002; 40(5): 1687 - 1693.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
M. Venter, S. A. Madhi, C. T. Tiemessen, and B. D. Schoub
Genetic diversity and molecular epidemiology of respiratory syncytial virus over four consecutive seasons in South Africa: identification of new subgroup A and B genotypes
J. Gen. Virol., September 1, 2001; 82(9): 2117 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
C. B. Hall
Respiratory Syncytial Virus and Parainfluenza Virus
N. Engl. J. Med., June 21, 2001; 344(25): 1917 - 1928.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
G. S. Taylor, I. B. Vipond, and E. O. Caul
Molecular Epidemiology of Outbreak of Respiratory Syncytial Virus within Bone Marrow Transplantation Unit
J. Clin. Microbiol., February 1, 2001; 39(2): 801 - 803.
[Abstract] [Full Text]

Home page
 J. Clin. Microbiol.Home page
L. E. Larsen, K. Tjørnehøj, and B. Viuff
Extensive Sequence Divergence among Bovine Respiratory Syncytial Viruses Isolated during Recurrent Outbreaks in Closed Herds
J. Clin. Microbiol., November 1, 2000; 38(11): 4222 - 4227.
[Abstract] [Full Text]

Home page
 J. Clin. Microbiol.Home page
A. H. Brandenburg, R. van Beek, H. A. Moll, A. D. M. E. Osterhaus, and E. C. J. Claas
G Protein Variation in Respiratory Syncytial Virus Group A Does Not Correlate with Clinical Severity
J. Clin. Microbiol., October 1, 2000; 38(10): 3849 - 3852.
[Abstract] [Full Text]

Home page
 Clin. Microbiol. Rev.Home page
W. M. Sullender
Respiratory Syncytial Virus Genetic and Antigenic Diversity
Clin. Microbiol. Rev., January 1, 2000; 13(1): 1 - 15.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. K. Shay, R. C. Holman, R. D. Newman, L. L. Liu, J. W. Stout, and L. J. Anderson
Bronchiolitis-Associated Hospitalizations Among US Children, 1980-1996
JAMA, October 20, 1999; 282(15): 1440 - 1446.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1998 by the Society for General Microbiology.