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The Inhibition of Vaccinia Virus DNA Synthesis in KB Cells Infected with Frog Virus 3

Groupe de Recherches sur la Pathogénie des Infections Virales de l'I.N.S.E.R.M. Institut de Bactériologie, 3 rue Koeberlé, 67-Strasbourg France

In KB cells doubly infected with vaccinia virus and Frog virus 3 (FV 3) at 37°, a non-permissive temperature for FV 3, the replication of vaccinia virus DNA was inhibited. The inhibition, which was as effective with gamma-irradiated or heat-inactivated virus as with live FV 3, was dependent upon the multiplicity of infection with FV 3. A 50% inhibition of vaccinia DNA synthesis was observed when the cells were pretreated with 0.2 p.f.u./cell of purified FV 3. Inhibition was not related to a toxic effect of FV 3 on the cells, as there was no auto-inhibition of the replicating FV 3 DNA in KB cells incubated 3 hr at 37° before incubation at 26°.

Received 30 December 1969; accepted 19 March 1970.