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Ultrastructural Features of Canine Distemper Virus Infection of the Chorioallantoic Membrane of the Hen's Egg

Lister Institute of Preventive Medicine, London

The chick embryo chorio-allantoic membrane was examined 6 days after inoculation of the ONDESTEPOORT strain of canine distemper virus. Multinucleated cells containing cytoplasmic inclusions were observed in the chorionic epithelium. These inclusions consisted of randomly arranged nucleocapsid filaments. The filaments had an outer lightly staining layer of radial fibrils in addition to their dense core. Budding and mature virus particles were observed less frequently. The morphological stages of distemper virus replication resembled those reported for measles and rinderpest viruses in other systems.

Received 5 March 1970; accepted 23 April 1970.