| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: RNA Viruses |
POWIC, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK1
Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi 484, Japan 2
Author for correspondence: Timothy J. Crow.Fax +44 1865 244990. e-mail tim.crow{at}psychiatry.oxford.ac.uk
An investigation was undertaken of primate pol gene sequences from a novel endogenous retrovirus family, ERV-W, related to a new human endogenous retrovirus family (HERV-W) that includes multiple sclerosis-associated retrovirus (MSRV) sequences identified in particles recovered from monocyte cultures from patients with multiple sclerosis. The pol gene sequences of the ERV-W family were detected in hominoids and Old World monkeys, but not in New World monkeys, whereas ERV-W long terminal repeat-like elements were detected in all primates (hominoids, Old World monkeys and New World monkeys). Thirty-two pol gene sequences from hominoids and Old World monkeys showed a high degree of sequence identity to MSRV and other HERV-W sequences. Phylogenetic analysis indicated close relationships of pol gene sequences across primate species. The analysis suggests that the ERV-W family has evolved independently but in constrained patterns (`parallel evolution') in different primate species, including man. The ratio of synonymous to non- synonymous substitutions indicated that negative selective pressure is acting on CHW1-1 from chimpanzee, HBW6-6 from baboon and HWX5 from man, sequences that have no disruption by point mutation or insertions/deletions. Therefore, these pol gene sequences could be associated with an active provirus in primates. The findings indicate that the ERV-W family has continued to evolve in the course of the primate radiation and may include members with a capacity to influence gene function and possibly cause disease.
This article has been cited by other articles:
|
|
 |
|
  S. Ohkura, M. W. Yap, T. Sheldon, and J. P. Stoye All Three Variable Regions of the TRIM5{alpha} B30.2 Domain Can Contribute to the Specificity of Retrovirus Restriction. J. Virol., September 1, 2006; 80(17): 8554 - 8565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Caceres, NISC Comparative Sequencing Program, and J. W. Thomas The Gene of Retroviral Origin Syncytin 1 is Specific to Hominoids and is Inactive in Old World Monkeys J. Hered., March 1, 2006; 97(2): 100 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Song, B. Gold, C. O'hUigin, H. Javanbakht, X. Li, M. Stremlau, C. Winkler, M. Dean, and J. Sodroski The B30.2(SPRY) Domain of the Retroviral Restriction Factor TRIM5{alpha} Exhibits Lineage-Specific Length and Sequence Variation in Primates J. Virol., May 15, 2005; 79(10): 6111 - 6121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Song, H. Javanbakht, M. Perron, D. H. Park, M. Stremlau, and J. Sodroski Retrovirus Restriction by TRIM5{alpha} Variants from Old World and New World Primates J. Virol., April 1, 2005; 79(7): 3930 - 3937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bonnaud, O. Bouton, G. Oriol, V. Cheynet, L. Duret, and F. Mallet Evidence of Selection on the Domesticated ERVWE1 env Retroviral Element Involved in Placentation Mol. Biol. Evol., October 1, 2004; 21(10): 1895 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Tonjes and M. Niebert Relative Age of Proviral Porcine Endogenous Retrovirus Sequences in Sus scrofa Based on the Molecular Clock Hypothesis J. Virol., November 15, 2003; 77(22): 12363 - 12368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P N Nelson, P R Carnegie, J Martin, H Davari Ejtehadi, P Hooley, D Roden, S Rowland-Jones, P Warren, J Astley, and P G Murray Demystified . . . Human endogenous retroviruses Mol. Pathol., February 1, 2003; 56(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lavillette, M. Marin, A. Ruggieri, F. Mallet, F.-L. Cosset, and D. Kabat The Envelope Glycoprotein of Human Endogenous Retrovirus Type W Uses a Divergent Family of Amino Acid Transporters/Cell Surface Receptors J. Virol., June 5, 2002; 76(13): 6442 - 6452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Costas Characterization of the Intragenomic Spread of the Human Endogenous Retrovirus Family HERV-W Mol. Biol. Evol., April 1, 2002; 19(4): 526 - 533. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
