J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Preikschat, P.
Right arrow Articles by Günther, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Preikschat, P.
Right arrow Articles by Günther, S.
Agricola
Right arrow Articles by Preikschat, P.
Right arrow Articles by Günther, S.
Journal of General Virology (1999), 80, 2685-2691.
© 1999 Society for General Microbiology

Animal: DNA Viruses

Hepatitis B virus genomes from long-term immunosuppressed virus carriers are modified by specific mutations in several regions

Petra Preikschat1, Helga Meisel1, Hans Will2 and Stephan Günther3

Institut für Medizinische Virologie der Charité, Humboldt-Universit ät zu Berlin, 10098 Berlin, Germany 1
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, 20251 Hamburg, Germany 2
Bernhard-Nocht-Institut für Tropenmedizin, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany 3

Author for correspondence: Stephan G ünther.Fax +49 40 42818 378. e-mail guenther{at}bni.uni-hamburg.de

There is increasing evidence that hepatitis B virus (HBV) infection of an immunosuppressed host is associated with the appearance of virus mutants. To characterize the virus circulating in patients in detail, eleven full-length HBV genomes, isolated from the serum of five highly viraemic renal transplant recipients with liver disease, were cloned and sequenced. The genomes contained deletions in the C gene, deletions in the pre-S1/2 region frequently removing the pre-S2 initiation codon, premature termination codons in the pre-S1 or S region, and/or deletions/insertions in the X gene/core promoter. The mutations occurred at different positions and in various combinations; even mutant genomes circulating within a patient differed strikingly. It is concluded that long-term immunosuppression is associated with the occurrence of heterogeneous populations of partially defective HBV characterized by a specific mutation pattern. Efficient intracellular trans-complementation probably enables high virus replication in vivo.




This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
P. Arauz-Ruiz, H. Norder, B. H. Robertson, and L. O. Magnius
Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America
J. Gen. Virol., August 1, 2002; 83(8): 2059 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
T. Nakano, L. Lu, X. Hu, M. Mizokami, E. Orito, C. N. Shapiro, S. C. Hadler, and B. H. Robertson
Characterization of hepatitis B virus genotypes among Yucpa Indians in Venezuela
J. Gen. Virol., February 1, 2001; 82(2): 359 - 365.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
S. Le Pogam, T. T.-T. Yuan, G. K. Sahu, S. Chatterjee, and C. Shih
Low-Level Secretion of Human Hepatitis B Virus Virions Caused by Two Independent, Naturally Occurring Mutations (P5T and L60V) in the Capsid Protein
J. Virol., October 1, 2000; 74(19): 9099 - 9105.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1999 by the Society for General Microbiology.