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Animal: DNA Viruses |
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK1
Author for correspondence: Geoffrey L. Smith.Fax +44 1865 275501. e- mail glsmith{at}molbiol.ox.ac.uk
Vaccinia virus (VV) proteins that interfere with the host response to infection are of interest because they provide insight into virus–host relationships and may affect the safety and immunogenicity of recombinant VV (rVV) vaccines. Such vaccines need assessment in animal models and with this aim a model of VV infection based on intradermal injection of BALB/c ear pinnae was developed and characterized. In this model, the outcome of infection is affected by the dose of virus inoculated but virus spread is minimal and the mice suffer no signs of systemic illness. Cellular and humoral immune responses to these infections were measured readily and were independent of virus dose over a 100-fold range. Thus the model seems suitable for the analysis of the safety and immunogenicity of VV mutants lacking specific immunomodulatory proteins or bearing foreign antigens.
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J. A. Symons, E. Adams, D. C. Tscharke, P. C. Reading, H. Waldmann, and G. L. Smith The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model J. Gen. Virol., November 1, 2002; 83(11): 2833 - 2844. [Abstract] [Full Text] [PDF]
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J. A. Symons, D. C. Tscharke, N. Price, and G. L. Smith A study of the vaccinia virus interferon-{gamma} receptor and its contribution to virus virulence J. Gen. Virol., August 1, 2002; 83(8): 1953 - 1964. [Abstract] [Full Text] [PDF]
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N. Bartlett, J. A. Symons, D. C. Tscharke, and G. L. Smith The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence J. Gen. Virol., August 1, 2002; 83(8): 1965 - 1976. [Abstract] [Full Text] [PDF]
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D. C. Tscharke, P. C. Reading, and G. L. Smith Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes J. Gen. Virol., August 1, 2002; 83(8): 1977 - 1986. [Abstract] [Full Text] [PDF]
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A. Ng, D. C. Tscharke, P. C. Reading, and G. L. Smith The vaccinia virus A41L protein is a soluble 30 kDa glycoprotein that affects virus virulence J. Gen. Virol., September 1, 2001; 82(9): 2095 - 2105. [Abstract] [Full Text] [PDF]
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