Journal of General Virology, Vol 80, 391-398, Copyright © 1999 by Society for General Microbiology

ARTICLES

Sexual behaviour and papillomavirus exposure in cervical intraepithelial neoplasia: a population-based case-control study

L Kjellberg, Z Wang, F Wiklund, K Edlund, T Angstrom, P Lenner, I Sjoberg, G Hallmans, KL Wallin, M Sapp, J Schiller, G Wadell, CG Mahlck and J Dillner
Department of Obstetrics and Gynecology, University Hospital of Northern Sweden, Umea.

Sexual history is an established risk determinant for cervical neoplasia. It is not clear if human papillomavirus (HPV) exposure entirely explains the sexual behaviour-related risk or if other sexually transmitted agents may act as cofactors for HPV in carcinogenesis. The aim of this study was to elucidate whether HPV exposure or HPV persistence explains the sexual history-related risk of high-grade cervical intraepithelial neoplasia (CIN) using a population- based case-control study of most of the 254 women referred to colposcopy in the Vasterbotten county in Sweden because of an abnormal cervical smear during October 1993 to December 1995 and 320 age-matched women from the general population. The women were interviewed for sexual history and tested for presence of serum antibodies to HPV-16, - 18 and -33 as well as for presence of HPV DNA in cervical brush samples. HPV-16, -18 and -33 seropositivity was specific for the corresponding type of HPV DNA, dependent on the lifetime sexual history and associated with a two- to threefold increased risk of CIN 3. There was no sexual history-related risk of CIN among HPV-seropositive women and adjustment for HPV DNA presence explained the sexual history- related risk of CIN. In conclusion, HPV exposure appeared to explain the sexual history-related risk of high-grade CIN.

This article has been cited by other articles:

				A. S. Kapeu, T. Luostarinen, E. Jellum, J. Dillner, M. Hakama, P. Koskela, P. Lenner, A. Love, E. Mahlamaki, S. Thoresen, et al. Is Smoking an Independent Risk Factor for Invasive Cervical Cancer? A Nested Case-Control Study Within Nordic Biobanks Am. J. Epidemiol., February 15, 2009; 169(4): 480 - 488. [Abstract] [Full Text] [PDF]

				N. P. Dickson, J. Ryding, T. van Roode, C. Paul, P. Herbison, J. Dillner, and D. C.G. Skegg Male Circumcision and Serologically Determined Human Papillomavirus Infection in a Birth Cohort Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 177 - 183. [Abstract] [Full Text] [PDF]

				S. Gorander, T. Lagergard, M. Romanik, R. P. Viscidi, G. Martirosian, and J.-A. Liljeqvist Seroprevalences of Herpes Simplex Virus Type 2, Five Oncogenic Human Papillomaviruses, and Chlamydia trachomatis in Katowice, Poland Clin. Vaccine Immunol., April 1, 2008; 15(4): 675 - 680. [Abstract] [Full Text] [PDF]

				P. Naucler, H.-C. Chen, K. Persson, S.-L. You, C.-Y. Hsieh, C.-A. Sun, J. Dillner, and C.-J. Chen Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case-control study J. Gen. Virol., March 1, 2007; 88(3): 814 - 822. [Abstract] [Full Text] [PDF]

				T. S. Shields, L. A. Brinton, R. D. Burk, S. S. Wang, S. J. Weinstein, R. G. Ziegler, Y. Y. Studentsov, M. McAdams, and M. Schiffman A Case-Control Study of Risk Factors for Invasive Cervical Cancer among U.S. Women Exposed to Oncogenic Types of Human Papillomavirus Cancer Epidemiol. Biomarkers Prev., October 1, 2004; 13(10): 1574 - 1582. [Abstract] [Full Text] [PDF]

				Y. Y. Studentsov, G. Y. F. Ho, M. A. Marks, R. Bierman, and R. D. Burk Polymer-Based Enzyme-Linked Immunosorbent Assay Using Human Papillomavirus Type 16 (HPV16) Virus-Like Particles Detects HPV16 Clade-Specific Serologic Responses J. Clin. Microbiol., July 1, 2003; 41(7): 2827 - 2834. [Abstract] [Full Text] [PDF]

				M. Lehtinen, P. Koskela, E. Jellum, A. Bloigu, T. Anttila, G. Hallmans, T. Luukkaala, S. Thoresen, L. Youngman, J. Dillner, et al. Herpes Simplex Virus and Risk of Cervical Cancer: A Longitudinal, Nested Case-Control Study in the Nordic Countries Am. J. Epidemiol., October 1, 2002; 156(8): 687 - 692. [Abstract] [Full Text] [PDF]

				A. Touze, S. de Sanjose, P. Coursaget, M. R. Almirall, V. Palacio, C. J. L. M. Meijer, J. Kornegay, and F. X. Bosch Prevalence of Anti-Human Papillomavirus Type 16, 18, 31, and 58 Virus-Like Particles in Women in the General Population and in Prostitutes J. Clin. Microbiol., December 1, 2001; 39(12): 4344 - 4348. [Abstract] [Full Text] [PDF]

				L.-M. AALTONEN, E. AUVINEN, J. DILLNER, M. LEHTINEN, J. PAAVONEN, H. RIHKANEN, and A. VAHERI Poor antibody response against human papillomavirus in adult-onset laryngeal papillomatosis J. Med. Microbiol., May 1, 2001; 50(5): 468 - 471. [Abstract] [Full Text] [PDF]

				J. Mork, A. K. Lie, E. Glattre, S. Clark, G. Hallmans, E. Jellum, P. Koskela, B. Moller, E. Pukkala, J. T. Schiller, et al. Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck N. Engl. J. Med., April 12, 2001; 344(15): 1125 - 1131. [Abstract] [Full Text] [PDF]

				I. Silins, I. Kallings, and J. Dillner Correlates of the Spread of Human Papillomavirus Infection Cancer Epidemiol. Biomarkers Prev., September 1, 2000; 9(9): 953 - 959. [Abstract] [Full Text]

				J. H. Nelson, G. A. Hawkins, K. Edlund, M. Evander, L. Kjellberg, G. Wadell, J. Dillner, T. Gerasimova, A. L. Coker, L. Pirisi, et al. A Novel and Rapid PCR-Based Method for Genotyping Human Papillomaviruses in Clinical Samples J. Clin. Microbiol., February 1, 2000; 38(2): 688 - 695. [Abstract] [Full Text]