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Journal of General Virology, Vol 80, 477-483, Copyright © 1999 by Society for General Microbiology
ARTICLES |
PG Stevenson, RD Cardin, JP Christensen and PC Doherty
St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.
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E. Flano, D. L. Woodland, and M. A. Blackman Requirement for CD4+ T Cells in V{beta}4+CD8+ T Cell Activation Associated with Latent Murine Gammaherpesvirus Infection J. Immunol., September 15, 1999; 163(6): 3403 - 3408. [Abstract] [Full Text] [PDF]
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P. G. Stevenson, G. T. Belz, M. R. Castrucci, J. D. Altman, and P. C. Doherty A gamma -herpesvirus sneaks through a CD8+ T cell response primed to a lytic-phase epitope PNAS, August 3, 1999; 96(16): 9281 - 9286. [Abstract] [Full Text] [PDF]
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J. P. Christensen, R. D. Cardin, K. C. Branum, and P. C. Doherty CD4+ T cell-mediated control of a gamma -herpesvirus in B cell-deficient mice is mediated by IFN-gamma PNAS, April 27, 1999; 96(9): 5135 - 5140. [Abstract] [Full Text] [PDF]
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G. T. Belz, P. G. Stevenson, M. R. Castrucci, J. D. Altman, and P. C. Doherty Postexposure vaccination massively increases the prevalence of gamma -herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice PNAS, March 14, 2000; 97(6): 2725 - 2730. [Abstract] [Full Text] [PDF]
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P. G. Stevenson, S. Efstathiou, P. C. Doherty, and P. J. Lehner Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses PNAS, July 18, 2000; 97(15): 8455 - 8460. [Abstract] [Full Text] [PDF]
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