J Gen Virol Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hsu, S. C.
Right arrow Articles by Steward, M. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hsu, S. C.
Right arrow Articles by Steward, M. W.
Agricola
Right arrow Articles by Hsu, S. C.
Right arrow Articles by Steward, M. W.

Journal of General Virology, Vol 80, 1401-1405, Copyright © 1999 by Society for General Microbiology

ARTICLES

Synergistic effect of immunization with a peptide cocktail inducing antibody, helper and cytotoxic T-cell responses on protection against respiratory syncytial virus

SC Hsu, D Chargelegue, OE Obeid and MW Steward
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK

Respiratory syncytial virus (RSV)-specific cytotoxic T lymphocytes (CTL) or neutralizing antibodies can protect against RSV infection when induced separately by immunization with synthetic peptides. In the work described here, RSV-specific neutralizing antibodies and CTLs were induced after immunization with a cocktail of peptides consisting of a B-cell mimotope (S1S-MAP), a T-helper epitope (SH:45--60) and a CTL epitope linked to a fusion (F) peptide (F/M2:81--95) that were comparable to those induced by the peptides alone. Following challenge, a 190-fold reduction in RSV titre was observed in the lungs of peptide cocktail-immunized mice. The combination of RSV-specific humoral and cellular immunity induced by the peptide cocktail was thus more effective at clearing RSV than peptide-induced humoral or cellular immunity alone.


This article has been cited by other articles:


Home page
 J. Virol.Home page
W.-P. Woo, T. Doan, K. A. Herd, H.-J. Netter, and R. W. Tindle
Hepatitis B surface antigen vector delivers protective cytotoxic T-lymphocyte responses to disease-relevant foreign epitopes.
J. Virol., April 1, 2006; 80(8): 3975 - 3984.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
S. Jiang, N. J. Borthwick, P. Morrison, G. F. Gao, and M. W. Steward
Virus-specific CTL responses induced by an H-2Kd-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus
J. Gen. Virol., February 1, 2002; 83(2): 429 - 438.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. P. Velders, S. Weijzen, G. L. Eiben, A. G. Elmishad, P.-M. Kloetzel, T. Higgins, R. B. Ciccarelli, M. Evans, S. Man, L. Smith, et al.
Defined Flanking Spacers and Enhanced Proteolysis Is Essential for Eradication of Established Tumors by an Epitope String DNA Vaccine
J. Immunol., May 1, 2001; 166(9): 5366 - 5373.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. P. Simmons, T. Hussell, T. Sparer, G. Walzl, P. Openshaw, and G. Dougan
Mucosal Delivery of a Respiratory Syncytial Virus CTL Peptide with Enterotoxin-Based Adjuvants Elicits Protective, Immunopathogenic, and Immunoregulatory Antiviral CD8+ T Cell Responses
J. Immunol., January 15, 2001; 166(2): 1106 - 1113.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1999 by the Society for General Microbiology.