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Journal of General Virology (1999), 80, 2311-2313.
© 1999 Society for General Microbiology

Animal: RNA Viruses

Integrin {alpha}vß3 (vitronectin receptor) is a candidate receptor for the virulent echovirus 9 strain Barty

Birgit Nelsen-Salz1, Hans J. Eggers1 and Holger Zimmermannb,1

Institut für Virologie der Universität zu Köln, Fürst-Pückler-Str. 56, 50935 Köln, Germany1

Author for correspondence: Birgit Nelsen-Salz.Fax +49 221 4783902. e-mail birgit.nelsen-salz{at}medizin.uni-koeln.de

The enterovirus echovirus 9 strain Barty (E9/Barty) is pathogenic for newborn mice as well as for humans. In contrast to the apathogenic prototype strain Hill, strain Barty encodes an RGD motif in the C-terminal part of the structural protein VP1. Data are presented that show that E9/Barty binds its target cells via contact of the RGD motif to the {alpha}vß3 integrin (vitronectin receptor), whereas prototype Hill uses a different, still unidentified receptor site. Furthermore, virus titres of murine muscle tissue were compared after infection of newborn and 1-, 2-, 3- and 12-week-old mice. The replication capacity of the virus decreased dramatically with age of the infected mice. Since E9/Barty does not replicate or replicates only poorly in mice older than about 5 days, and expression of the vitronectin receptor is reported to be down-regulated in striated muscle tissue during development, it is suggested that susceptibility of mice to this echovirus infection is controlled by the availability of {alpha}vß3 integrin.




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