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Journal of General Virology (1999), 80, 2315-2317.
© 1999 Society for General Microbiology

Animal: RNA Viruses

Clearance of infection in cats naturally infected with feline coronaviruses is associated with an anti-S glycoprotein antibody response

V. Gonon1, V. Duquesne2, B. Klonjkowski2, M. Monteil1, A. Aubert2 and M. Eloit1

URA INRA de Génétique Moléculaire et Cellulaire, Génétique Virale, Ecole Nationale Vétérinaire d'Alfort, 94704 Maisons Alfort, France1
Virbac, BP 27, 06516 Carros, France2

Author for correspondence: M. Eloit.Fax +33 1 43 96 71 31. e-mail eloit{at}vet-alfort.fr

We have investigated by Western blotting the antibody responses against the three major structural proteins in cats naturally infected with feline coronaviruses that cleared virus infection (group I), established chronic asymptomatic infection (group II) or were sick (group III). The cats of group I developed an anti-S glycoprotein response that was, relative to the anti-M glycoprotein response, at least 30-fold higher than that of chronically infected cats from groups II and III. These results suggest that the anti-S glycoprotein response against antigenic domains revealed by Western blot is associated with clearance of the virus after natural infection, and is not a risk factor for the establishment of a chronic infection.




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