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Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hosts

Laboratoire de Virologie moléculaire, transfusionnelle et tropicale, Faculté de Médecine, 13385 Marseille, France¹
Dept of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA²

Author for correspondence: Rémi Charrel (at the Laboratoire de Virologie moléculaire, transfusionelle et tropicale).Fax +33 4 91 18 95 98. e-mail virophdm{at}lac2.gulliver.fr

GB viruses A and C (GBV-A and GBV-C) have been isolated from humans and non-human primates. Phylogenetic analysis based on full-length polyproteins suggests that these two viruses have a common ancestor. It has now been determined that analysis of subgenomic amino acid sequences in the E2 and NS5 regions of GBV-A and a 345 nucleotide segment in the 5' non-coding (5'NC) region was able to reproduce the phylogenetic relationships obtained by complete polyprotein sequences analysis. Using 5'NC sequences from databases, GBV-A isolates were discriminated into eight genetic groups, each one closely associated with specific primate hosts. Phylogenetic analyses performed on sequences from the -globin genes of primate hosts on one hand and complete polyprotein sequences from GBV-A and GBV-C isolates on the other suggest that a mechanism of cospeciation could be involved in virus evolution over a period of 35 million years.

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