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Journal of General Virology (1999), 80, 2393-2397.
© 1999 Society for General Microbiology

Animal: RNA Viruses

Endothelial cell infection in vivo by equine infectious anaemia virus

J. Lindsay Oaks1, Catherine Ulibarri2 and Timothy B. Crawford1

Departments of Veterinary Microbiology and Pathology1 and Veterinary and Comparative Anatomy, Pharmacology and Physiology2, Washington State University, PO Box 647040, Pullman, WA 99164-7040, USA

Author for correspondence: J. Lindsay Oaks.Fax +1 509 335 8529. e-mail loaks{at}vetmed.wsu.edu

Equine infectious anaemia virus (EIAV) infection of horses is characterized clinically by recurrent episodes of fever, thrombocytopenia and anaemia. In vivo, the only site of virus replication that has been previously demonstrated for EIAV is the tissue macrophage. In this study, in situ hybridization for EIAV was combined with immunohistochemistry for cell-type-specific markers to identify infected endothelial cells. EIAV-infected endothelial cells and macrophages were detected in horses infected with either virulent wild-type or with weakly virulent tissue culture-adapted strains of EIAV. The role of endothelial cell infection in the pathogenesis of EIAV remains undefined, but could contribute to the development of thrombocytopenia. However, endothelial cell infection does not appear to be a determinant of virulence for EIAV.




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