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Animal: DNA Viruses |
Departments of Pathology1 and Obstetrics and Gynaecology2, Free University Hospital, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK3
Department of Biology, YCR Cancer Research Unit, University of York, York, UK4
Author for correspondence: Jan Walboomers.Fax +31 20 4442964. e-mail jmm.walboomers{at}azvu.nl
T-cell-mediated immune responses against mucosal oncogenic types of human papillomaviruses (HPV) are thought to play a role in the control of the virus infection and its associated cervical lesions. The in vitro production of interleukin-2 by T-helper (Th) cells in response to the C-terminal and N-terminal domains of the HPV-16 E2 protein was determined in 74 women with cytological evidence of premalignant cervical epithelial neoplasia who participated in a non-intervention follow-up (FU) study. Cross-sectional analysis at the end of FU showed that Th cell responses against the C-terminal domain were associated with evidence of previous or present HPV-16 infection as compared to patients with no evidence of any HPV infection (18·9% versus 0%, P=0·039). Th cell responses against the N-terminal domain were not associated with evidence of HPV-16 infection. No association with disease outcome was observed with Th cell responses against either of the E2 protein domains. However, longitudinal analysis revealed that Th cell responses against the C-terminal domain frequently occur at the time of virus clearance. Whether these responses are responsible for the clearance of the virus is not known.
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