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Journal of General Virology (2000), 81, 129-133.
© 2000 Society for General Microbiology

Animal: RNA Viruses

The bulk of the phosphorylation of human respiratory syncytial virus phosphoprotein is not essential but modulates viral RNA transcription and replication

Nieves Villanueva1, Richard Hardy2, Ana Asenjo1, Qingzhong Yu2 and Gail Wertz2

Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo Km2, Majadahonda, Madrid 28220, Spain1
Department of Microbiology, BBRB 17/Rm 366, University of Alabama Medical School, Birmingham, AL 3594-2170, USA2

Author for correspondence: Nieves Villanueva. Fax +34 91 5097966. e-mail nvilla{at}isciii.es

The ability of variants of the human respiratory syncytial virus (HRSV) phosphoprotein (P protein) to support RNA transcription and replication has been studied by using HRSV-based subgenomic replicons. The serine residues normally phosphorylated in P during HRSV infection have been replaced by other residues. The results indicate that the bulk of phosphorylation of P (98%) is not essential for viral RNA transcription or replication but that phosphorylation can modulate these processes.




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