HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chibo, D. Articles by Catton, M. G. Search for Related Content PubMed PubMed Citation Articles by Chibo, D. Articles by Catton, M. G. Agricola Articles by Chibo, D. Articles by Catton, M. G.

Molecular characterization of measles viruses isolated in Victoria, Australia, between 1973 and 1998

Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne 3051, Victoria, Australia¹
Centers for Disease Control and Prevention, Atlanta, GA 30322, USA²

Author for correspondence: Doris Chibo. Fax +61 3 9342 2665. e-mail Doris.chibo{at}mh.org.au

Molecular epidemiology studies have made significant contributions to the control of measles virus infection through the identification of source and transmission pathways of the virus. These studies allow observation of changes in measles virus genotypes over time in a particular geographical location, clarification of epidemiological links during measles outbreaks, separation of indigenous strains from newly imported strains and distinction between vaccine- and wild-type virus-associated illness. A total of 35 wild-type measles viruses identified in Victoria, Australia, between 1973 and 1998 were characterized by nucleic acid sequence analysis of the nucleoprotein gene and, in some cases, the haemagglutinin gene. Relatedness between the viruses was studied and genotypes were assigned using a classification scheme recently proposed by the World Health Organization. Five recognized genotypes (C2, D1, D4, D5 and H) and one previously undescribed genotype, which we propose to be D7, were identified. Successive replacement of measles virus genetic lineages occurred in Victoria, with no evidence of temporal overlap, during this 25 year period. This pattern of circulation is likely to represent serial importation of wild-type measles virus strains from overseas foci of measles virus infections.

This article has been cited by other articles:

				A. A. Neverov, M. A. Riddell, W. J. Moss, D. V. Volokhov, P. A. Rota, L. E. Lowe, D. Chibo, S. B. Smit, D. E. Griffin, K. M. Chumakov, et al. Genotyping of measles virus in clinical specimens on the basis of oligonucleotide microarray hybridization patterns. J. Clin. Microbiol., October 1, 2006; 44(10): 3752 - 3759. [Abstract] [Full Text] [PDF]

				D. Chibo, M. A. Riddell, M. G. Catton, and C. J. Birch Applicability of Oral Fluid Collected onto Filter Paper for Detection and Genetic Characterization of Measles Virus Strains J. Clin. Microbiol., July 1, 2005; 43(7): 3145 - 3149. [Abstract] [Full Text] [PDF]

				S. Santibanez, A. Tischer, A. Heider, A. Siedler, and H. Hengel Rapid replacement of endemic measles virus genotypes J. Gen. Virol., November 1, 2002; 83(11): 2699 - 2708. [Abstract] [Full Text] [PDF]

				H. S. El Mubarak, M. W. G. van de Bildt, O. A. Mustafa, H. W. Vos, M. M. Mukhtar, S. A. Ibrahim, A. C. Andeweg, A. M. El Hassan, A. D. M. E. Osterhaus, and R. L. de Swart Genetic characterization of wild-type measles viruses circulating in suburban Khartoum, 1997-2000 J. Gen. Virol., June 1, 2002; 83(6): 1437 - 1443. [Abstract] [Full Text] [PDF]

				M. A. Riddell, D. Chibo, H. A. Kelly, M. G. Catton, and C. J. Birch Investigation of Optimal Specimen Type and Sampling Time for Detection of Measles Virus RNA during a Measles Epidemic J. Clin. Microbiol., January 1, 2001; 39(1): 375 - 376. [Abstract] [Full Text]