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Animal: RNA Viruses |
Department of Virology, Haartman Institute, University of Helsinki, FIN-00014 Helsinki, Finland1
Department of Forest Ecology, Finnish Forest Research Institute, FIN-01301 Vantaa, Finland2
Department of Anatomy, Faculty of Veterinary Medicine, University of Helsinki, FIN-00581, Helsinki, Finland3
Department of Clinical Microbiology, Aarhus University Hospital, 8000 Aarhus, Denmark4
Danish Pest Infestation Laboratory, 2800 Lyngby, Copenhagen, Denmark5
Author for correspondence: Alexander Plyusnin. Fax +358 9 1912 6491. e-mail Alexander.Plyusnin{at}Helsinki.Fi
Like other members of the genus Hantavirus in the family Bunyaviridae, Puumala virus (PUUV) is thought to be co-evolving with its natural host, the bank vole Clethrionomys glareolus. To gain insight into the evolutionary history of PUUV in northern Europe during the last post-glacial period, we have studied wild-type PUUV strains originating from areas along two postulated immigration routes of bank voles to Fennoscandia. Full-length sequences of the S RNA segment and partial sequences (nt 2168–2569) of the M segment were recovered by RT–PCR directly from bank vole tissues collected at three locations in Russian Karelia and one location in Denmark. Phylogenetic analysis showed that strains from Karelia and Finland belong to the same genetic lineage, supporting the hypothesis that PUUV spread to present Finland via a Karelian land-bridge. The Danish PUUV strains showed no particularly close relatedness to any of the known PUUV strains and formed a distinct phylogenetic lineage on trees calculated for both S and M segment sequences. Although no direct link between the Danish PUUV strains and those of the southern Scandinavian lineage was found, within the S segment of Danish PUUV strains, two regions with higher similarity to either northern Scandinavian or – to a less extent – southern Scandinavian genetic lineages were revealed, suggesting evolutionary connections of their precursors.
This article has been cited by other articles:
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  M. Razzauti, A. Plyusnina, T. Sironen, H. Henttonen, and A. Plyusnin Analysis of Puumala hantavirus in a bank vole population in northern Finland: evidence for co-circulation of two genetic lineages and frequent reassortment between strains J. Gen. Virol., August 1, 2009; 90(8): 1923 - 1931. [Abstract] [Full Text] [PDF]
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M. Razzauti, A. Plyusnina, H. Henttonen, and A. Plyusnin Accumulation of point mutations and reassortment of genomic RNA segments are involved in the microevolution of Puumala hantavirus in a bank vole (Myodes glareolus) population J. Gen. Virol., July 1, 2008; 89(7): 1649 - 1660. [Abstract] [Full Text] [PDF]
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J. W. Dragoo, J. A. Lackey, K. E. Moore, E. P. Lessa, J. A. Cook, and T. L. Yates Phylogeography of the deer mouse (Peromyscus maniculatus) provides a predictive framework for research on hantaviruses J. Gen. Virol., July 1, 2006; 87(7): 1997 - 2003. [Abstract] [Full Text] [PDF]
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 K. Hanada, Y. Suzuki, and T. Gojobori A Large Variation in the Rates of Synonymous Substitution for RNA Viruses and Its Relationship to a Diversity of Viral Infection and Transmission Modes Mol. Biol. Evol., June 1, 2004; 21(6): 1074 - 1080. [Abstract] [Full Text] [PDF]
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E. R. Chare, E. A. Gould, and E. C. Holmes Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses J. Gen. Virol., October 1, 2003; 84(10): 2691 - 2703. [Abstract] [Full Text] [PDF]
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 T. Sironen, A. Vaheri, and A. Plyusnin Molecular Evolution of Puumala Hantavirus J. Virol., December 1, 2001; 75(23): 11803 - 11810. [Abstract] [Full Text]
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