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Animal: RNA Viruses |
The Wohl Virion Centre, Department of Immunology and Molecular Pathology, The Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1P 6DB, UK1
Authors for correspondence: Paul Clapham (Fax +44 20 7679 9555; e-mail p.clapham{at}ucl.ac.uk) and Nathalie Dejucq (Fax +33 29 9281 613; e-mail nathalie.dejucq@rennes.inserm.fr).
Changes in co-receptor-use by human immunodeficiency virus type 1 (HIV-1) strains are relatively rare in vivo. Here we describe two variants derived from the CCR5-using strain SF162, selected for replication in the C8166 T-cell line. Amino acid substitutions in the V3 loop conferred CXCR4-use; however, the loss of macrophage-tropism by one variant was due to a single mutation in the start codon of vpu. We discuss how V3 loop and vpu mutations acquired by replication in T-cell lines in vitro correlate with similar changes reported for primary isolates and HIV-1 sequences in vivo.
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