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Journal of General Virology (2000), 81, 2919-2927.
© 2000 Society for General Microbiology

Animal: RNA Viruses

Restricted species tropism of maedi–visna virus strain EV-1 is not due to limited receptor distribution

J. W. Lyall1, N. Solanky1 and L. S. Tiley1

Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK1

Author for correspondence: Laurence Tiley. Fax +44 1223 337610. e-mail Lst21{at}cam.ac.uk

The distribution of receptors for maedi–visna virus (MVV) was studied using co-cultivation assays for virus fusion and PCR-based assays to detect the formation of virus-specific reverse transcription products after virus entry. Receptors were present on cell lines from human, monkey, mouse, chicken, quail, hamster and ovine sources. Thus, the distribution of the receptor for MVV is more similar to that of the amphotropic type C retroviruses than to that of other lentiviruses. The receptor was sensitive to proteolysis by papain, but was resistant to trypsin. Chinese hamster ovary (CHO) and lung cells (V79 TOR) did not express functional receptors for MVV. The receptor was mapped to either chromosome 2 or 4 of the mouse using somatic cell hybrids. This allowed several candidates (e.g. MHC-II, CXCR4) that have been proposed for the MVV receptor to be excluded.




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