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Journal of General Virology (2000), 81, 689-694.
© 2000 Society for General Microbiology

Animal: DNA Viruses

Binding of bovine papillomavirus type 4 E8 to ductin (16K proteolipid), down-regulation of gap junction intercellular communication and full cell transformation are independent events

G. Hossein Ashrafi1, John D. Pitts2, AnnaMaria Faccini2, Pauline McLean2, Vincent O’Brien1, Malcolm E. Finbowb,2 and Saveria Campo1

Papillomavirus Group1 and Cell Communication Group2, The Beatson Institute for Cancer Research, Glasgow, UK

Author for correspondence: Saveria Campo. Present address: Department of Veterinary Pathology, Glasgow University, Garscube Estate, Glasgow G61 1QH, UK. Fax +44 141 330 5602. e-mail s.campo{at}udcf.gla.ac.uk

The E8 open reading frame of bovine papillomavirus type 4 encodes a small hydrophobic polypeptide that contributes to primary cell transformation by conferring to cells the ability to form foci and to grow in low serum and in suspension. Wild-type E8 binds in vitro to ductin, a component of gap junctions, and this binding is accompanied by a loss of gap junction intercellular communication in transformed bovine fibroblasts. However, through the analysis of a panel of E8 mutants, we show here that binding of E8 to ductin is not sufficient for down-regulation of gap junction communication and that there is no absolute correlation between down-regulation of gap junction communication and the transformed phenotype.




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