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Journal of General Virology (2000), 81, 695-700.
© 2000 Society for General Microbiology

Animal: DNA Viruses

The effects of interferon on the expression of human papillomavirus oncogenes

Kelly Y. Kim1, Lawrence Blattb,1 and Milton W. Taylor1

Department of Biology, Indiana University, Bloomington, IN 47405, USA1

Author for correspondence: Milton Taylor. Fax +1 812 855 6705. e-mail taylor{at}indiana.edu

The effects of interferon (IFN)-{alpha}, IFN-{beta} and IFN-{gamma} on human papillomavirus (HPV) oncogene expression were studied in various cervical carcinoma cell lines containing integrated copies of either HPV type 16 or HPV type 18. The levels of E6 and E7 transcripts were examined 6 h and 30 h after treatment with IFN. In HeLa cells, all three classes of IFNs effected a decrease in the level of HPV-18 E6 and E7 transcripts. On the other hand, none of the IFNs altered the level of these transcripts in C-4II cells. Only IFN-{gamma} decreased the level of HPV-16 E6 and E7 transcripts in CaSki and HPK1A cells, while IFN-{gamma} actually increased the level of these transcripts in SiHa cells. This differential IFN regulation of HPV expression in various cervical cancer cell lines may account for the contradictory clinical results observed after treatment of cervical cancer with IFN.




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