| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: RNA Viruses |
Laboratoire de Virologie Moléculaire, Tropicale et Transfusionnelle, Unité des Virus Emergents, Faculté de Médecine de Marseille, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France1
National Environment Research Council Institute of Virology and Environmental Microbiology, Oxford, UK2
Author for correspondence: Xavier de Lamballerie. Fax +334 91 32 44 95. e-mail xndl-virophdm{at}mail.gulliver.fr
Attempts to define the evolutionary relationships and origins of viruses in the genus Flavivirus are hampered by the lack of genetic information particularly amongst the non-vectored flaviviruses. Using a novel protocol for sequence determination, the first complete coding sequence of St Louis encephalitis virus and those of two representative non-vectored flaviviruses, Rio Bravo (isolated from bat) and Apoi (isolated from rodent), are reported. The encoded polyproteins of Rio Bravo and Apoi virus are the smallest described to date within the genus Flavivirus. The highest similarities with other flaviviruses were found in the NS3 and NS5 genes. The proteolytic cleavage sites for the viral serine protease were highly conserved among the flaviviruses completely sequenced to date. Comparative genetic amino acid alignments revealed that p-distance cut-off values of 0·330–0·470 distinguished the arthropod-borne viruses according to their recognized serogroups and Rio Bravo and Apoi virus were assigned to two distinct non-vectored virus groups. Within these serogroups, cladogenesis based on the complete ORF sequence was similar to trees based on envelope and NS5 sequences. In contrast, branching patterns at the deeper nodes of the tree were different from those reported in the previous study of NS5 sequences. The significance of these observations is discussed.
This article has been cited by other articles:
|
|
 |
|
  D. B. A. Medeiros, M. R. T. Nunes, P. F. C. Vasconcelos, G.-J. J. Chang, and G. Kuno Complete genome characterization of Rocio virus (Flavivirus: Flaviviridae), a Brazilian flavivirus isolated from a fatal case of encephalitis during an epidemic in Sao Paulo state J. Gen. Virol., August 1, 2007; 88(8): 2237 - 2246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Grard, J.-J. Lemasson, M. Sylla, A. Dubot, S. Cook, J.-F. Molez, X. Pourrut, R. Charrel, J.-P. Gonzalez, U. Munderloh, et al. Ngoye virus: a novel evolutionary lineage within the genus Flavivirus. J. Gen. Virol., November 1, 2006; 87(Pt 11): 3273 - 3277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cook, S. N. Bennett, E. C. Holmes, R. De Chesse, G. Moureau, and X. de Lamballerie Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico. J. Gen. Virol., April 1, 2006; 87(Pt 4): 735 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Niyomrattanakit, P. Winoyanuwattikun, S. Chanprapaph, C. Angsuthanasombat, S. Panyim, and G. Katzenmeier Identification of Residues in the Dengue Virus Type 2 NS2B Cofactor That Are Critical for NS3 Protease Activation J. Virol., December 15, 2004; 78(24): 13708 - 13716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Mutebi, R. C. A. Rijnbrand, H. Wang, K. D. Ryman, E. Wang, L. D. Fulop, R. Titball, and A. D. T. Barrett Genetic Relationships and Evolution of Genotypes of Yellow Fever Virus and Other Members of the Yellow Fever Virus Group within the Flavivirus Genus Based on the 3' Noncoding Region J. Virol., September 15, 2004; 78(18): 9652 - 9665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kumar, P. Sulochana, G. Nirmala, M. Haridattatreya, and V. Satchidanandam Conserved amino acids 193-324 of non-structural protein 3 are a dominant source of peptide determinants for CD4+ and CD8+ T cells in a healthy Japanese encephalitis virus-endemic cohort J. Gen. Virol., May 1, 2004; 85(5): 1131 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. de Lamballerie, S. Crochu, F. Billoir, J. Neyts, P. de Micco, E. C. Holmes, and E. A. Gould Genome sequence analysis of Tamana bat virus and its relationship with the genus Flavivirus J. Gen. Virol., October 1, 2002; 83(10): 2443 - 2454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charlier, P. Leyssen, C. W. A. Pleij, P. Lemey, F. Billoir, K. Van Laethem, A.-M. Vandamme, E. De Clercq, X. de Lamballerie, and J. Neyts Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector J. Gen. Virol., August 1, 2002; 83(8): 1875 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Gaunt, A. A. Sall, X. d. Lamballerie, A. K. I. Falconar, T. I. Dzhivanian, and E. A. Gould Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography J. Gen. Virol., August 1, 2001; 82(8): 1867 - 1876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Attoui, J. M. Stirling, U. G. Munderloh, F. Billoir, S. M. Brookes, J. N. Burroughs, P. de Micco, P. P. C. Mertens, and X. de Lamballerie Complete sequence characterization of the genome of the St Croix River virus, a new orbivirus isolated from cells of Ixodes scapularis J. Gen. Virol., April 1, 2001; 82(4): 795 - 804. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
