| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: DNA Viruses |
Department of Virology, Haartman Institute, PL 21 (Haartmaninkatu 3), FIN-00014 University of Helsinki, Helsinki, Finland1
Central Military Hospital2, Dextra Medical Centre3 and Departments of Anatomy, Oral Medicine and Rheumatology, University of Helsinki4, Helsinki, Finland
Author for correspondence: Klaus Hedman. Fax +358 9 1912 6491. e-mail klaus.hedman{at}helsinki.fi
Primary infection by human parvovirus B19 is often accompanied by arthropathy of varying duration, of which the most severe cases can be indistinguishable from rheumatoid arthritis (RA). While this might seem to imply a role in RA pathogenesis, recent studies have verified long-term persistence of B19 DNA in synovial tissue not only in patients with rheumatoid or juvenile arthritis, but also in immunocompetent, non-arthritic individuals with a history of prior B19 infection. However, the latter data are based on PCR amplification of short segments of DNA, with little sequence information. We determined the nucleotide sequence and examined the integrity of the protein-coding regions of B19 genomes persisting in synovial tissue and compared the results with data from synovial tissues of recently infected patients. In synovium of both previously and recently infected subjects, the viral coding regions were found to be present in an apparently continuous, intact DNA molecule. Comparison with sequences reported from blood or bone marrow showed that the synoviotropism or persistence of the B19 virus DNA was not due to exceptional mutations or particular genotype variants. The synovial retention of full-length viral genomes may represent a physiological process functioning in long-term storage of foreign macromolecules in this tissue.
This article has been cited by other articles:
|
|
 |
|
  P. Norja, A. M. Eis-Hubinger, M. Soderlund-Venermo, K. Hedman, and P. Simmonds Rapid Sequence Change and Geographical Spread of Human Parvovirus B19: Comparison of B19 Virus Evolution in Acute and Persistent Infections J. Virol., July 1, 2008; 82(13): 6427 - 6433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ekman, K. Hokynar, L. Kakkola, K. Kantola, L. Hedman, H. Bonden, M. Gessner, C. Aberham, P. Norja, S. Miettinen, et al. Biological and Immunological Relations among Human Parvovirus B19 Genotypes 1 to 3 J. Virol., July 1, 2007; 81(13): 6927 - 6935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Norja, K. Hokynar, L.-M. Aaltonen, R. Chen, A. Ranki, E. K. Partio, O. Kiviluoto, I. Davidkin, T. Leivo, A. M. Eis-Hubinger, et al. Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue PNAS, May 9, 2006; 103(19): 7450 - 7453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Poole, Y. V. Karetnyi, and S. J. Naides Parvovirus B19-Induced Apoptosis of Hepatocytes J. Virol., July 15, 2004; 78(14): 7775 - 7783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hokynar, P. Norja, H. Laitinen, P. Palomaki, A. Garbarg-Chenon, A. Ranki, K. Hedman, and M. Soderlund-Venermo Detection and Differentiation of Human Parvovirus Variants by Commercial Quantitative Real-Time PCR Tests J. Clin. Microbiol., May 1, 2004; 42(5): 2013 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Servant, S. Laperche, F. Lallemand, V. Marinho, G. De Saint Maur, J. F. Meritet, and A. Garbarg-Chenon Genetic Diversity within Human Erythroviruses: Identification of Three Genotypes J. Virol., August 12, 2002; 76(18): 9124 - 9134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Kerr and W. M. H. Behan High mutation rate in the NS1 gene of parvovirus B19 DNA amplified from skeletal muscle of a case of mixed connective tissue disease Rheumatology, July 1, 2002; 41(7): 833 - 834. [Full Text] [PDF]
|
|
|
|
|
|
V. V. Lukashov and J. Goudsmit Evolutionary Relationships among Parvoviruses: Virus-Host Coevolution among Autonomous Primate Parvoviruses and Links between Adeno-Associated and Avian Parvoviruses J. Virol., March 15, 2001; 75(6): 2729 - 2740. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Dorsch, B. Kaufmann, U. Schaible, E. Prohaska, H. Wolf, and S. Modrow The VP1-unique region of parvovirus B19: amino acid variability and antigenic stability J. Gen. Virol., January 1, 2001; 82(1): 191 - 199. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
