J Gen Virol Try IJSEM Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johne, R.
Right arrow Articles by Müller, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johne, R.
Right arrow Articles by Müller, H.
Agricola
Right arrow Articles by Johne, R.
Right arrow Articles by Müller, H.
Journal of General Virology (2000), 81, 1183-1190.
© 2000 Society for General Microbiology

Animal: DNA Viruses

Agnoprotein 1a and agnoprotein 1b of avian polyomavirus are apoptotic inducers

Reimar Johne1, Annett Jungmann1 and Hermann Müller1

Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D-04103 Leipzig, Germany1

Author for correspondence: Hermann Müller. Fax +49 341 9738219. e-mail virology{at}vetmed.uni-leipzig.de

Avian polyomavirus (APV) causes an acute fatal disease in a variety of avian species. DNA laddering indicating apoptosis was demonstrated in APV-infected chicken embryo (CE) cells. DNA laddering, however, was not observed in Vero cells infected with mammalian polyomavirus simian virus 40. Expression of APV agnoprotein 1a and agnoprotein 1b induced apoptosis in insect cells and CE cells. An APV full-length plasmid transfected in CE cells induced apoptosis, and infectious virus was produced. After transfection of CE cells with a plasmid containing a mutated initiation codon for agnoprotein 1a and agnoprotein 1b, however, a considerably lower number of apoptotic cells was observed, and no infectious progeny was produced.




This article has been cited by other articles:


Home page
 J. Virol.Home page
R. Johne and H. Muller
Polyomaviruses of Birds: Etiologic Agents of Inflammatory Diseases in a Tumor Virus Family
J. Virol., November 1, 2007; 81(21): 11554 - 11559.
[Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
R. Johne, G. Paul, D. Enderlein, T. Stahl, C. Grund, and H. Muller
Avian polyomavirus mutants with deletions in the VP4-encoding region show deficiencies in capsid assembly and virus release, and have reduced infectivity in chicken
J. Gen. Virol., March 1, 2007; 88(3): 823 - 830.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Johne, W. Wittig, D. Fernandez-de-Luco, U. Hofle, and H. Muller
Characterization of two novel polyomaviruses of birds by using multiply primed rolling-circle amplification of their genomes.
J. Virol., April 1, 2006; 80(7): 3523 - 3531.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Johne and H. Muller
Nuclear Localization of Avian Polyomavirus Structural Protein VP1 Is a Prerequisite for the Formation of Virus-Like Particles
J. Virol., January 15, 2004; 78(2): 930 - 937.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
R. Johne and H. Müller
Avian polyomavirus agnoprotein 1a is incorporated into the virus particle as a fourth structural protein, VP4
J. Gen. Virol., April 1, 2001; 82(4): 909 - 918.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2000 by the Society for General Microbiology.