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Germinal centre localization of bovine viral diarrhoea virus in persistently infected animals

Institute for Animal Health, Compton, Newbury RG20 7NN, UK¹

Author for correspondence: Bryan Charleston. Fax +44 1635 577263. e-mail bryan.charleston{at}bbsrc.ac.uk

Immunohistochemical analysis of peripheral lymph nodes from gnotobiotic calves persistently infected with bovine viral diarrhoea virus (BVDV) revealed extensive deposition of E^rns and localization of the viral genome in the light zone of germinal centres. Viral antigen co-localized with immunoglobulin in the germinal centres and was shown to be extracellular. Despite the presence of viral antigen in germinal centres, circulating anti-BVDV antibody was not detected. These findings provide evidence that calves persistently infected with BVDV, in the absence of adventitious infection, can generate a B cell response to the persisting virus. The nature of the tolerance in calves persistently infected with BVDV is discussed in light of these findings.

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